114744-08-0

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 114744-07-9 3-[(2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester 
• 110-87-2 3,4-dihydro-2H-pyran 
• 10457-16-6 2',3',5,-tris-O-(trimethylsilyl)uridine 
• 58-96-8 uridine 
• 114744-06-8 2,6-Dioxo-3-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester 
• 114744-05-7 3-((2R,3R,3aS,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester 
• 114744-04-6 3-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester 

Downstream Products

• 124735-97-3 3-[(2R,3R,4R,5R)-4-[(5-Chloro-quinolin-8-yloxy)-(2,6-dichloro-phenoxy)-phosphoryloxy]-5-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-yl]-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbothioic acid S-butyl ester 
• 116113-47-4 C₅₅H₅₃Cl₃N₃O₁₃PS 

Relevant academic research and scientific papers

USE OF THE (BUTYLTHIO)CARBONYL GROUP TO PROTECT URACIL AND GUANINE RESIDUES IN OLIGORIBONUCLEOTIDE SYNTHESIS

We describe the protection of the O6-amide group of guanosine and the N3-imide group of uridine with the (butylthio)carbonyl group.This group is introduced in good yields and is cleaved under mild conditions.KEYWORDS--uracil residue protection; guanine residue protection; (butylthio)carbonyl group; oligoribonucleotide; phosphorylation; coupling reaction