114772-38-2

Basic information

• Product Name: Methyl 4'-bromomethyl biphenyl-2-carboxylate
• Synonyms: METHYL 2-[4-(BROMOMETHYL)PHENYL]BENZOATE;METHYL 4'-BROMOMETHYL-2-BIPHENYLCARBOXYLATE;METHYL 4'-(BROMOMETHYL)BIPHENYL-2-CARBOXYLATE;METHYL-4-(BROMOMETHYL)-BIPHENYL-2-CARBOXYLATE;2-[4-(BROMOMETHYL)PHENYL]BENZOIC ACID METHYL ESTER;4'-(BROMOMETHYL)BIPHENYL-2-CARBOXYLIC ACID METHYL ESTER;4'-BROMOMETHYL-(1,1'-BIPHENYL)-2-CARBOXYLIC ACID METHYL ESTER;4’-methyl-1,1’-biphenyl-2-carboxylicacidmethylester
• CAS NO: 114772-38-2
• Molecular Formula: C₁₅H₁₃BrO₂
• Molecular Weight: 305.17
• EINECS: 1308068-626-2
• Product Categories: Chemical intermediate for Telmisartan;INTERMEDIATESOF;Biphenyl & Diphenyl ether;(intermediate of telmisartan);Hypertension;Aromatics;Other Products
• Mol File: 114772-38-2.mol
• Article Data: 30

Chemical Properties

• Melting Point: 56 °C
• Boiling Point: 412.8 °C at 760 mmHg
• Flash Point: 203.5 °C
• Appearance: off-white solid
• Density: 1.374 g/cm³
• Vapor Pressure: 0.001-0.002Pa at 20-25℃
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: soluble in Toluene
• CAS DataBase Reference: Methyl 4'-bromomethyl biphenyl-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4'-bromomethyl biphenyl-2-carboxylate(114772-38-2)
• EPA Substance Registry System: Methyl 4'-bromomethyl biphenyl-2-carboxylate(114772-38-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 114772-38-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Upstream product

• 57598-33-1 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 128-08-5 N-Bromosuccinimide 
• 114772-34-8 methyl 4'-methylbiphenyl-2-carboxylate 
• 34241-39-9 azobisisobutyronitrile 
• 114772-53-1 2-Cyano-4'-methylbiphenyl 
• 67-56-1 methanol 
• 7148-03-0 o-tolylbenzoic acid 
• 2042-37-7 o-cyanobromobenzene 
• 50-00-0 formaldehyd 
• 16605-99-5 biphenyl-2-carboxylic acid methyl ester 
• 947-84-2 2-Biphenylcarboxylic acid 
• 106-38-7 para-bromotoluene 
• 158144-38-8 4,4-dimethyl-2-(4'-tetrahydropyranyloxymethylbiphenyl-2-yl)oxazoline 
• 158144-50-4 2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-carboxylic acid 

Downstream Products

• 138459-20-8 methyl 4'-<(2-butylimidazo<1,2-a>pyridin-3-yl)methyl>biphenyl-2-carboxylate 
• 143494-69-3 methyl 4'-<(3-ethyl-1,4-dihydro-4-oxoquinolinyl)methyl>biphenyl-2-carboxylate 
• 135015-63-3 Methyl 4'-[[(2-butyl-4-quinolinyl)-oxy]-methyl](1,1'-biphenyl)-2-carboxylate 
• 139743-06-9 4'-{[(2-Methoxycarbonyl-6-nitro-phenyl)-pentanoyl-amino]-methyl}-biphenyl-2-carboxylic acid methyl ester 
• 151322-75-7 methyl 2-amino>pyridine-3-carboxylate 
• 194416-99-4 Methyl 4'-(benzotriazol-1-yl)methylbiphenyl-2-carboxylate 
• 194416-97-2 Methyl 4'-(naphtho[2,3-d]imidazol-1-yl)methylbiphenyl-2-carboxylate 
• 194417-01-1 Methyl 4'-(naphtho[2,3-d][1,2,3]triazol-1-yl)methyl-biphenyl-2-carboxylate 
• 133075-99-7 4'-[(2-butyl-1H-benzimidazol-1-yl)methyl]biphenyl-2-carboxylic acid 
• 152147-96-1 2-butyl-1-<(2'-carbomethoxy<1,1'-biphenyl>-4-yl)methyl>-1H-imidazole-5-carboxaldehyde 
• 133141-61-4 4'-[(Benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid 
• 138459-12-8 4'-(2-Butyl-indol-1-ylmethyl)-biphenyl-2-carboxylic acid 
• 114799-00-7 2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-5-(hydroxymethyl)imidazole 
• 114798-32-2 2-(1E-Butenyl)-4-chloro-1-[(2'-carboxybiphenyl-4-yl)methyl]-5-(hydroxymethyl)imidazole 

Relevant articles and documents

Synthesis method of 4-bromomethyl-2-methyl formate biphenyl

The invention discloses a synthesis method of 4-bromomethyl-2-methyl formate biphenyl. The method comprises the following steps: performing bromination reaction in a mode of synchronously dropwise adding bromine and hydrogen peroxide, re-oxidizing hydrobromic acid formed after the reaction into bromine, and performing bromination reaction again, so that the bromine can fully participate in the reaction so as to reduce the use amount of bromine raw materials and improve the yield of the 4-bromomethyl-2-methyl formate biphenyl, waste difficult to treat cannot be generated, hydrogen peroxide is cheap and easy to obtain, and the production cost is remarkably saved.

Synthetic method of 4'-bromomethylbiphenyl-2-carboxylate

The invention discloses a synthetic method of 4'-bromomethylbiphenyl-2-carboxylate. The synthetic method comprises the following steps: 1, hydrolyzing 4'-methyl-2-cyanobiphenyl to obtain 4'-methyl-2-biphenyl formic acid; 2, esterifying 4'-methyl-2-biphenyl formic acid to obtain 4'-methyl-2-biphenyl formate; and 3, reacting 4'-methyl-2-biphenyl formate under the illumination of 15000-20000lx at 20-30DEG C for 4-6h to obtain 4'-bromomethylbiphenyl-2-carboxylate. The synthetic method of 4'-bromomethylbiphenyl-2-carboxylate allows 4'-bromomethylbiphenyl-2-carboxylate to be obtained after hydrolysis, esterification and bromination of 4'-methyl-2-cyanobiphenyl used as an initial material. The route of the method is short, so the problem of raw material waste caused by bromine removal and bromo group introduction is avoided; and a bromination reaction is an illumination reaction, so 4'-bromomethylbiphenyl-2-carboxylate can be directly used in telmisartan synthesis without purifying, thereby the cost is reduced.

Synthesis of new biphenyl-substituted quinoline derivatives, preliminary screening and docking studies

New quinoline derivatives containing biphenyl ring were synthesized and characterized by IR, 1H NMR and mass spectral studies. The synthesized compounds were screened for antimicrobial, anthelmintic activities as well as free radical scavenging property against the DPPH radical. The minimum inhibition concentration values showed promising inhibiting activity and are potent biological agents. The compounds showed minimum binding energy towards ?-tubulin. The compounds 11a, 11c, 13c and 13d have good affinity towards the active pocket and may be considered as a good inhibitor of β-tubulin. Indian Academy of Sciences.