114772-78-0

Basic information

• Product Name: (4'-METHYL-1,1'-BIPHENYL-2-YL)METHANOL
• Synonyms: (4'-METHYL-1,1'-BIPHENYL-2-YL)METHANOL;[1,1'-Biphenyl]-2-Methanol, 4'-Methyl-;(4'-Methylbiphenyl-2-yl)-methanol
• CAS NO: 114772-78-0
• Molecular Formula: C₁₄H₁₄O
• Molecular Weight: 198.26036
• Mol File: 114772-78-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 41.5-43.0 °C
• Boiling Point: 360.5±21.0 °C(Predicted)
• Appearance: /
• Density: 1.072±0.06 g/cm3(Predicted)
• PKA: 14.52±0.10(Predicted)
• CAS DataBase Reference: (4'-METHYL-1,1'-BIPHENYL-2-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4'-METHYL-1,1'-BIPHENYL-2-YL)METHANOL(114772-78-0)
• EPA Substance Registry System: (4'-METHYL-1,1'-BIPHENYL-2-YL)METHANOL(114772-78-0)

Safety Data

• Hazardous Substances Data: 114772-78-0(Hazardous Substances Data)

Usage

General Description

(4'-Methyl-1,1'-biphenyl-2-yl)methanol is a chemical compound with a molecular formula C14H14O. It is a white crystalline solid that is commonly used as a precursor in the synthesis of various pharmaceuticals and organic compounds. (4'-METHYL-1,1'-BIPHENYL-2-YL)METHANOL has been found to have potential biological activity and is being studied for its potential use in medicinal applications. It is also used in the production of dyes, pigments, and other industrial chemicals. However, it is important to handle this compound with care as it may have certain hazardous properties and can cause irritation to the skin, eyes, and respiratory system if not properly handled.

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Relevant articles and documents

A new vinyl ether type linker for solid-phase synthesis

A new vinyl ether type of linker based on 4.-hydroxy phenethyl alcohol is developed for the solid-phase synthesis as demonstrated in the Suzuki type of aryl-aryl coupling reaction for the preparation of various biphenyl tetrazole derivatives. (C) 2000 Elsevier Science Ltd.

6-Arylphenanthridines from Aryl o-Biaryl Ketones with 1,1,1,3,3,3-Hexamethyldisilazane and Molecular Iodine

Warming treatment of aryl o-biaryl ketones with 1,1,1,3,3,3-hexamethyldisilazane in the presence of Sc(OTf)3 in toluene, followed by the reaction with molecular iodine and K2CO3 in a mixture of THF and methanol at 60 °C gave the corresponding 6-arylphenanthridines in good to moderate yields. The present reaction is a one-pot method for the preparation of 6-arylphenanthridines from aryl o-biaryl ketones through the cyclization of imino-nitrogen-centered radicals that were generated from N-iodo aryl o-biaryl ketimines formed from the reaction of aryl biaryl ketimines with molecular iodine.

Synthesis and use of phenylpropionic acid derivatives

The invention discloses a series of phenylpropionic acid derivatives, a preparation method thereof, and a use of the derivatives in pharmacy. The derivatives are compounds represented by formula I. Pharmacodynamic experiments show that the compounds of formula I have good agonist activity to GPR120; an in-vivo metabolism research result shows that the compounds of the formula I have good metabolism stability; and unexpectedly, the compounds have substantially higher agonist activity to the GPR120 after a difluoro substitute group is introduced to a phenyl ring at the carboxyl terminal of the compounds of the formula I. The compounds of the formula I can be used for drugs for preventing diabetes, obesity and other metabolic diseases.