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(R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid, also known as R-HHPA, is a versatile organic compound with a molecular formula C12H10O3. It is a derivative of phenylpropiolic acid and features a unique structure that includes both an alkyne and a phenolic group. This characteristic makes R-HHPA a valuable building block in organic synthesis and medicinal chemistry, with potential applications in the development of new pharmaceuticals.

1147732-37-3

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1147732-37-3 Usage

Uses

Used in Pharmaceutical Industry:
R-HHPA is used as a central nervous system depressant and analgesic for its potential to alleviate pain and anxiety. Its structure allows for the development of drugs that can target specific receptors in the nervous system, providing effective pain relief and calming effects.
Used in Anti-inflammatory Applications:
R-HHPA is used as a selective COX-2 inhibitor, which makes it a promising candidate for the development of new anti-inflammatory drugs. By inhibiting the COX-2 enzyme, R-HHPA can help reduce inflammation and associated pain without the side effects commonly associated with non-selective COX inhibitors.
Used in Anti-cancer Research:
R-HHPA is used in the study of its potential anti-cancer properties. Its unique structure may allow for the development of drugs that can target cancer cells specifically, leading to new treatments for various types of cancer.
Used in Organic Synthesis:
R-HHPA is used as a versatile building block in the synthesis of various bioactive molecules. Its alkyne and phenolic groups provide opportunities for the creation of new compounds with potential applications in medicine, agriculture, and other fields.

Check Digit Verification of cas no

The CAS Registry Mumber 1147732-37-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,7,7,3 and 2 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1147732-37:
(9*1)+(8*1)+(7*4)+(6*7)+(5*7)+(4*3)+(3*2)+(2*3)+(1*7)=153
153 % 10 = 3
So 1147732-37-3 is a valid CAS Registry Number.

1147732-37-3Relevant academic research and scientific papers

3-PHENYL-4-HEXYNOIC ACID DERIVATIVES AS GPR40 AGONISTS

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Page/Page column 43, (2019/07/23)

A compound of the formula (I)wherein R represents a straight or branched, primary or secondary acyclic hydrocarbyl C3–C15 group, which can be saturated or unsaturated, or a straight or branched, primary or secondary acyclic hydrocarbyl C3–C15 group, which can be saturated or unsaturated and wherein one or more of hydrogen atoms is replaced with fluorine atom; X represents hydrogen atom or halogen atom,and* denotes chiral center, and salts thereof. The compound is useful for the treatment of diseases mediated by GPR40, in particular type II diabetes. (I)

Novel Spiropiperidine Compounds

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Page/Page column 10, (2011/05/03)

A compound of the formula: or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition, and a method for treating diabetes.

SPIRO COMPOUNDS AND PHARMACEUTICAL USE THEREOF

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Page/Page column 61; 62, (2009/07/17)

The Spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof

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