1147732-37-3

Basic information

• Product Name: (R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid
• Synonyms: (R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid;(R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid（WS203620）;(3R)-3-(4-Hydroxy phenyl)-4-hexynoic acid
• CAS NO: 1147732-37-3
• Molecular Formula: C₁₂H₁₂O₃
• Molecular Weight: 204.22188
• Mol File: 1147732-37-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 398.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.234±0.06 g/cm3(Predicted)
• PKA: 4.23±0.10(Predicted)
• CAS DataBase Reference: (R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid(1147732-37-3)
• EPA Substance Registry System: (R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid(1147732-37-3)

Safety Data

• Hazardous Substances Data: 1147732-37-3(Hazardous Substances Data)

Usage

General Description

The chemical (R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid, also known as R-HHPA, is a compound with a molecular formula C12H10O3. It is a derivative of phenylpropiolic acid and is commonly used in organic synthesis and medicinal chemistry. R-HHPA has been studied for its potential as a central nervous system depressant and analgesic, as well as its potential anti-inflammatory and anti-cancer properties. Its unique structure, containing both an alkyne and a phenolic group, makes it a versatile building block for the synthesis of various bioactive molecules. Additionally, R-HHPA has shown potential as a selective COX-2 inhibitor, making it a promising candidate for the development of new anti-inflammatory drugs.

Upstream product

• 865233-34-7 4-hydroxy-β-1-propyn-1-ylbenzenepropanoic acid 
• 1147732-38-4 (R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid (R)-α-methylbenzylamine salt 

Downstream Products

• 1147732-38-4 (R)-3-(4-hydroxyphenyl)-hex-4-ynoic acid (R)-α-methylbenzylamine salt 
• 929713-77-9 (3R)-3-(4-hydroxyphenyl)hex-4-ynoic acid methyl ester 
• 1356181-74-2 (R)-ethyl 3-(4-hydroxyphenyl)hex-4-ynoate 

Relevant articles and documents

3-PHENYL-4-HEXYNOIC ACID DERIVATIVES AS GPR40 AGONISTS

A compound of the formula (I)wherein R represents a straight or branched, primary or secondary acyclic hydrocarbyl C3–C15 group, which can be saturated or unsaturated, or a straight or branched, primary or secondary acyclic hydrocarbyl C3–C15 group, which can be saturated or unsaturated and wherein one or more of hydrogen atoms is replaced with fluorine atom; X represents hydrogen atom or halogen atom,and* denotes chiral center, and salts thereof. The compound is useful for the treatment of diseases mediated by GPR40, in particular type II diabetes. (I)

SPIRO COMPOUNDS AND PHARMACEUTICAL USE THEREOF

The Spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof