1147752-20-2Relevant academic research and scientific papers
Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases
Grolla, Ambra A.,Podestà, Valeria,Chini, Maria Giovanna,Di Micco, Simone,Vallario, Antonella,Genazzani, Armando A.,Canonico, Pier Luigi,Bifulco, Giuseppe,Tron, Gian Cesare,Sorba, Giovanni,Pirali, Tracey
experimental part, p. 2776 - 2785 (2010/02/28)
HDAC inhibitors show great promise for the treatment of cancer. As part of a broader effort to explore the SAR of HDAC inhibitors, synthesis, biological evaluation, and molecular docking of novel Ugi products containing a zinc-chelating moiety are presented. One compound shows improved inhibitory potencies compared to SAHA, demonstrating that hindered lipophilic residues grafted on the peptide scaffold of the α-aminoacylamides can be favorable in the interaction with the enzyme.
