114780-17-5Relevant academic research and scientific papers
Stereoselective synthesis and biological activities of O-(E)-1-{1-[6- chloropyridin-3-yhmethyl]-5-methyl-1 H-1,2,3-triazol-4-yl}ethyleneamino-O-ethyl- O-arylphosphorothioates
Zhu, XiaoFei,Chen, XiaoBao,Yan, Man,Shi, De-Qing,Ding, Ke-Rong
, p. 15 - 20 (2008)
To find novel lead compounds having high insecticidal activity, a series of phosphorothioate derivatives containing 1,2,3-triazole and pyridine rings were synthesized by the reaction of 1-{1-[(6-chloropyridin-3-yl)methyl]-5-methyl-1H- 1,2,3-triazol-4-yl}e
Anti-Lung Cancer Activities of 1,2,3-Triazole Curcumin Derivatives via Regulation of the MAPK/NF-κB/STAT3 Signaling Pathways
Zhi, Tai Xin,Liu, Kai Qiang,Cai, Kun Yi,Zhao, Yu Chao,Li, Zhen Wang,Wang, Xin,He, Xin Hua,Sun, Xian Yu
, (2021/12/01)
In this study, a series of curcumin derivatives containing 1,2,3-triazole were designed and synthesized, and their inhibitory activities against the proliferation of lung cancer cells were studied. Compound 5 k (3,4-dichlorobenzyltriazole methyl curcumin)
Carcarinic acid-1, 2, 3- based triazole compound as well as preparation method and application thereof (by machine translation)
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Paragraph 0217-0219, (2019/12/25)
The method comprises the following steps: firstly 1, 2, 3 - oxidizing and opening the carbon- carbon double bond of the, carcarinic acid into methylene to, obtain carcarinic acid (not shown, in the technical field of, organic 3 - synthesis), Wolf - Kishner - 1, 2, 3 - 1, 2, 3 - 1, 2, 3 - 3 . (by machine translation)
Synthesis and herbicidal activity of O,O-dialkyl(phenyl)-N-{1-[(6- chloropyridin-3-yl)methyl]-4-cyano-1H-1,2,3-triazol-5-yl}-1-amino-1- substitutedbenzyl-phosphonates
Tang, Wu,Shi, De-Qing
experimental part, p. 496 - 502 (2011/05/07)
A series of novel -amino phosphonate derivatives containing both pyridine and 1,2,3-triazole moieties 4 were synthesized via a multi-step reaction. First, the condensation of 5-amino-1-[(6-chloropyridin-3-yl) methyl]-4-cyano-1H-1,2,3- triazole with various aromatic aldehydes in the presence of magnesium perchlorate afforded imines 3 in moderate yields; second, imines 3 reacted with dialkyl phosphites or triphenyl phosphite to give the title compounds 4 in moderate to good yields. Their structures were elucidated by spectroscopic data (IR, 1H NMR, 31P NMR, ESI-MS) and elemental analysis. The preliminary bioassay (in vitro) indicated that some of the title compounds 4 possessed moderate herbicidal activities against dicotyledonous plants (Brassica campestris L) at a concentration of 100 mg/L. However, compounds 4 did not exhibit herbicidal activities against Brassica campestris L at a concentration of 10 mg/L. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright Taylor & Francis Group, LLC.
Synthesis and biological activities of O-(E)-(arylmethyl) 1-[1-(arylmethyl)-5-methyl-1H-1,2,3-triazol-4-yl] ethanone oxime ethers
Zhu, Xiao-Fei,Shi, De-Qing
body text, p. 1218 - 1221 (2010/03/04)
(Chemical Equation Presented) A series of novel O-(E)-(arylmethyl) 1-[1-(arylmethyl)-5-methyl-1H-1,2,3-triazol-4-yl] ethanone oxime ethers were synthesized by the O-alkylation of 1-[1-(arylmethyl)-5-methyl-1H-1,2,3-triazol- 4-yl] ethanone oximes with various arylmethyl chlorides in the basic condition. Their structures were confirmed by IR, 1H NMR, mass spectroscopy, and elemental analyses. The preliminary bioassay indicated that some of the target compounds (4a-f) displayed good insecticidal and moderate fungicidal activity. For example, compounds 4c and 4g showed 100% and 90.6% death rates against aphides at the concentration of 250 mg/L, respectively, and compounds 4f and 4g displayed 67% and 78.4% inhibitory rates against Rhizoctonia solani at the dosage of 100 mg/L, respectively.
Synthesis and biological activity of novel phosphonate derivatives containing of pyridyl and 1,2,3-triazole rings
Chen, Xiao-Bao,Shi, De-Qing
experimental part, p. 1134 - 1144 (2009/04/10)
In order to search for novel agrochemicals with high activity and low toxicity, a series of phosphonate derivatives containing 1,2,3-triazolyl and pyridyl rings were synthesized using 2-chloro-5-(chloromethyl)-pyridine as the starting material. IR, 1 H NM
