1148009-63-5Relevant academic research and scientific papers
Hydroarylation of Arenes via Reductive Radical-Polar Crossover
Flynn, Autumn R.,Mcdaniel, Kelly A.,Hughes, Meredith E.,Vogt, David B.,Jui, Nathan T.
, p. 9163 - 9168 (2020/07/10)
A photocatalytic system for the dearomative hydroarylation of benzene derivatives has been developed. Using a combination of an organic photoredox catalyst and an amine reductant, this process operates through a reductive radical-polar crossover mechanism where aryl halide reduction triggers a regioselective radical cyclization event, followed by anion formation and quenching to produce a range of complex spirocyclic cyclohexadienes. This light-driven protocol functions at room temperature in a green solvent system (aq. MeCN) without the need for precious metal-based catalysts or reagents or the generation of stoichiometric metal byproducts.
Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists
Sakamoto, Toshihiro,Moriya, Minoru,Haga, Yuji,Takahashi, Toshiyuki,Shibata, Takunobu,Okamoto, Osamu,Nonoshita, Katsumasa,Kitazawa, Hidefumi,Hidaka, Masayasu,Gomori, Akira,Iwaasa, Hisashi,Ishihara, Akane,Kanatani, Akio,Fukami, Takehiro,Gao, Ying-Duo,MacNeil, Douglas J.,Yang, Lihu
scheme or table, p. 1564 - 1568 (2009/12/07)
A series of spiroindoline-3,4′-piperidine derivatives were synthesized and evaluated for their binding affinities and antagonistic activities at Y5 receptors. Potent Y5 antagonists were tested for their oral bioavailabilities and brain penetration in rats
