1148010-40-5Relevant academic research and scientific papers
Inhibitory activity of prostaglandin E2 production by the synthetic 2′-hydroxychalcone analogues: Synthesis and SAR study
Tran, Thanh-Dao,Park, Haeil,Kim, Hyun Pyo,Ecker, Gerhard F.,Thai, Khac-Minh
, p. 1650 - 1653 (2009)
A series of 2′-hydroxychalcones has been synthesized and screened for their in vitro inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin production from lipopolysaccharide-treated RAW 264.7 cells. Structure-activity relationship study suggested that inhibitory activity against prostaglandin E2 production was governed to a greater extent by the substituent on B ring of the chalcone, and most of the active compounds have at least two methoxy or benzyloxy groups on B ring. The relationship between chalcone structures and their PGE2 inhibitory activities was also interpreted by docking study on cyclooxygenase-2.
Microwave-assisted synthesis of macrocycles via intramolecular and/or bimolecular Ullmann coupling
Shen, Li,Simmons, Charles J.,Sun, Dianqing
scheme or table, p. 4173 - 4178 (2012/08/28)
Microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling is described. Using the optimized conditions, a panel of macrocycles, with different substitution patterns, ring sizes, and linkers, has been successfully synthesized using microwave irradiation. To the best of our knowledge, this work represents the first examples of the microwave-assisted synthesis of macrocyclic diaryl ethers via intramolecular and/or bimolecular Ullmann coupling.
