1148034-07-4Relevant academic research and scientific papers
Impact of planarity of unfused aromatic molecules on G-quadruplex binding: Learning from isaindigotone derivatives
Hou, Jin-Qiang,Tan, Jia-Heng,Wang, Xiao-Xiao,Chen, Shuo-Bin,Huang, Si-Yuan,Yan, Jin-Wu,Chen, Shu-Han,Ou, Tian-Miao,Luo, Hai-Bin,Li, Ding,Gu, Lian-Quan,Huang, Zhi-Shu
scheme or table, p. 6422 - 6436 (2011/10/10)
G-quadruplex structures are a new class of attractive targets for DNA-interactive anticancer agents. The primary building block of this structure is the G-quartet, which is composed of four coplanar guanines and serves as the major binding site for small
Isaindigotone derivatives: A new class of highly selective ligands for telomeric G-quadruplex DNA
Tan, Jia-Heng,Ou, Tian-Miao,Hou, Jin-Qiang,Lu, Yu-Jing,Huang, Shi-Liang,Luo, Hai-Bin,Wu, Jian-Yong,Huang, Zhi-Shu,Wong, Kwok-Yin,Gu, Lian-Quan
experimental part, p. 2825 - 2835 (2010/02/28)
Four isaindigotone derivatives (5a,b and 6a,b) designed as telomeric G-quadruplex ligands have been synthesized and characterized. The unfused aromatic rings in these compounds allow a flexible and adaptive conformation in G-quadruplex recognition. The in
