1148041-57-9

Basic information

• Product Name: 5-[(4-bromophenyl)(hydroxy)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione
• Synonyms: 5-[(4-bromophenyl)(hydroxy)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS NO: 1148041-57-9
• Molecular Weight: 327.131
• Mol File: 1148041-57-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-[(4-bromophenyl)(hydroxy)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(4-bromophenyl)(hydroxy)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione(1148041-57-9)
• EPA Substance Registry System: 5-[(4-bromophenyl)(hydroxy)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione(1148041-57-9)

Safety Data

• Hazardous Substances Data: 1148041-57-9(Hazardous Substances Data)

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 586-75-4 4-chlorobenzoyl chloride 
• 586-76-5 4-Bromobenzoic acid 

Downstream Products

• 1148041-59-1 C₁₅H₁₁BrINO₂ 

Relevant articles and documents

5-Carbonyl-1,3-oxazine-2,4-diones from N-Cyanosulfoximines and Meldrum's Acid Derivatives

At elevated temperatures, N-cyanosulfoximines react with Meldrum's acid derivatives to give sulfoximines with N-bound 5-carbonyl-1,3-oxazine-2,4-dione groups. A representative product was characterized by single-crystal X-ray structure analysis. The product formation involves an unexpected molecular reorientation requiring several sequential bond-forming and-cleaving processes.

Acyl/aroyl Meldrum's acid as an enol surrogate for the direct organocatalytic synthesis of α,β-unsaturated ketones

The operationally simple, robust and straightforward organocatalytic protocol is developed for the synthesis of E-selective α,β-unsaturated ketones. The method utilizes simple and easily accessible starting materials such as Meldrum's acid, carboxylic acid, aldehyde and simple bifunctional amine catalyst. The tandem organocatalytic process utilizes acyl/aroyl Meldrum's acid as an enol surrogate for the effective Doebner-Knoevenagel type condensation reactions. A wide variety of aldehydes, carboxylic acids and base sensitive functional groups are well tolerated under the mild reaction conditions.

PROCESS FOR PREPARING AN ANTI-HYPERCHOLESTEROLEMIC COMPOUND

The present invention relates to a process for preparing inhibitors of cholesterol absorption of Formula II: II and the pharmaceutically acceptable salts and esters thereof, employing a metal-catalyzed dynamic kinetic resolution (DKR) asymmetric transfer hydrogenation (ATH) reaction of racemic acyclic ?-ketoamide bearing a-substituted aliphatic side chain (Intermediate A) and subsequent cyclization of the resulting b-hydroxyamide product (Intermediate B), followed by a synthesis involving two consecutive cross-coupling reactions.