1148041-65-9Relevant academic research and scientific papers
PROCESS FOR PREPARING AN ANTI-HYPERCHOLESTEROLEMIC COMPOUND
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Page/Page column 29; 34; 58-60, (2009/05/30)
The present invention relates to a process for preparing inhibitors of cholesterol absorption of Formula II: II and the pharmaceutically acceptable salts and esters thereof, employing a metal-catalyzed dynamic kinetic resolution (DKR) asymmetric transfer hydrogenation (ATH) reaction of racemic acyclic ?-ketoamide bearing a-substituted aliphatic side chain (Intermediate A) and subsequent cyclization of the resulting b-hydroxyamide product (Intermediate B), followed by a synthesis involving two consecutive cross-coupling reactions.
