1148041-68-2Relevant academic research and scientific papers
PROCESS FOR PREPARING AN ANTI-HYPERCHOLESTEROLEMIC COMPOUND
-
Page/Page column 61-62, (2009/05/30)
The present invention relates to a process for preparing inhibitors of cholesterol absorption of Formula II: II and the pharmaceutically acceptable salts and esters thereof, employing a metal-catalyzed dynamic kinetic resolution (DKR) asymmetric transfer hydrogenation (ATH) reaction of racemic acyclic ?-ketoamide bearing a-substituted aliphatic side chain (Intermediate A) and subsequent cyclization of the resulting b-hydroxyamide product (Intermediate B), followed by a synthesis involving two consecutive cross-coupling reactions.
