114805-34-4Relevant academic research and scientific papers
STEREOCONTROL IN RADICAL CYCLIZATION: STEREOSELECTIVE SYNTHESIS OF 2,4-CIS AND 2,4-TRANS TETRAHYDROFURAN DERIVATIVES VIA MONO- OR DICHLOROMETHYL RADICAL.
Watanabe, Yoshihiko,Endo, Takeshi
, p. 321 - 324 (1988)
A novel stereocontrol method for the preparation of 2,4-disubstituted tetrahydrofurans was presented. 2,4-Cis-disubstituted-3,3-dichlorotetrahydrofurans 2 were provided predominantly by the radical cyclization of allyl-2,2,2-trichloroethylethers 1 with tributyltin hydride.The effect of geometry of chlorine atom and olefin on products stereochemistry was also discussed.
