1148050-91-2Relevant academic research and scientific papers
PYRAZOLO-PYRIDINONE DERIVATIVES AND METHODS OF USE
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Page/Page column 48, (2009/05/30)
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of pro-inflammatory cytokine mediated diseases, and in particular, p38 activity mediated inflammation and related conditions. The compounds have a general Fo
Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase
Wurz, Ryan P.,Pettus, Liping H.,Xu, Shimin,Henkle, Bradley,Sherman, Lisa,Plant, Matthew,Miner, Kent,McBride, Helen,Wong, Lu Min,Saris, Christiaan J.M.,Lee, Matthew R.,Chmait, Samer,Mohr, Christopher,Hsieh, Faye,Tasker, Andrew S.
scheme or table, p. 4724 - 4728 (2010/05/17)
A novel class of fused pyrazole-derived inhibitors of p38α mitogen-activated protein kinase (MAPK) is disclosed. These inhibitors were evaluated for their ability to inhibit the p38α enzyme, the secretion of TNFα in a LPS-challenged THP1 cell line and TNF
