114849-59-1

Basic information

• Product Name: 2-fluoro-2',3'-dideoxyadenosine
• Synonyms: 18: PN:WO03035012 PAGE: 53 claimed sequence; 2-Fluoro-2',3'-dideoxyadenosine
• CAS NO: 114849-59-1
• Molecular Formula: C₁₀H₁₂FN₅O₂
• Molecular Weight: 253.23
• Mol File: 114849-59-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-fluoro-2',3'-dideoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-2',3'-dideoxyadenosine(114849-59-1)
• EPA Substance Registry System: 2-fluoro-2',3'-dideoxyadenosine(114849-59-1)

Safety Data

• Hazardous Substances Data: 114849-59-1(Hazardous Substances Data)

Upstream product

• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 

Downstream Products

• 122970-32-5 2',3'-Dideoxy-2-(methylthio)adenosine 

Relevant articles and documents

A Highly Stereoselective Synthesis of Anti-HIV 2',3'-Dideoxy- and 2',3'-Didehydro-2',3'-dideoxynucleosides

A general total synthesic method for the stereocontrolled synthesis of 2',3'-dideoxy- as well as 2',3'-didehydro-2',3'-dideoxynucleosides is presented.Introduction of an α-phenylselenenyl group at the 2-position of 2,3-dideoxyribosyl acetate directs the glycosyl bond formation to give >/=95percent β-isomer.This 2'-phenylselenenyl nucleoside may be converted to either the 2',3'-dideoxynucleoside by treatment with n-Bu3SnH and Et3B at room temperature or to the unsaturated derivative by treatment with H2O2/cat. pyridine.The application of this method to the syntheses of pyrimidines (ddU, ddT, ddC), 6-substituted purines (ddA, ddI, 6-chloro-ddP, N6-Me-ddA), and 2,6-disubstituted purines (2-F-ddA, 6-chloro-2-amino-ddP) as well as selected 2',3'-didehydro-2',3'-dideoxy derivatives is reported.