114853-61-1

Basic information

• Product Name: (R)-1-(4-CHLOROPHENYL)PROPAN-1-AMINE-HCl
• Synonyms: (R)-1-(4-CHLOROPHENYL)PROPAN-1-AMINE-HCl;(R)-1-(4-Chlorophenyl)propan-1-aMine hydrochloride;(R) 1-(4-CHLOROPHENYL)PROPYLAMINE;(1R)-1-(4-CHLOROPHENYL)PROPAN-1-AMINE
• CAS NO: 114853-61-1
• Molecular Formula: C₉H₁₂ClN
• Molecular Weight: 206.11222
• Mol File: 114853-61-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 244.3±15.0 °C(Predicted)
• Appearance: /
• Density: 1.093±0.06 g/cm3(Predicted)
• PKA: 9.13±0.10(Predicted)
• CAS DataBase Reference: (R)-1-(4-CHLOROPHENYL)PROPAN-1-AMINE-HCl(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(4-CHLOROPHENYL)PROPAN-1-AMINE-HCl(114853-61-1)
• EPA Substance Registry System: (R)-1-(4-CHLOROPHENYL)PROPAN-1-AMINE-HCl(114853-61-1)

Safety Data

• Hazardous Substances Data: 114853-61-1(Hazardous Substances Data)

Usage

General Description

The chemical (R)-1-(4-chlorophenyl)propan-1-amine-HCl, also known as Norephedrine hydrochloride, is a pharmaceutical compound that acts as a sympathomimetic agent, stimulating the adrenergic receptors in the body. It is a derivative of amphetamine and is used as a nasal decongestant and appetite suppressant. Due to its stimulating effects on the central nervous system, it has also been used as a recreational drug. However, it has potential for abuse and addiction, and its recreational use is regulated or prohibited in many countries. The hydrochloride form of the compound is stable and soluble, making it suitable for pharmaceutical applications.

Upstream product

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Relevant articles and documents

Synthesis of highly enantiomerically enriched amines by the diastereoselective addition of triorganozincates to N-(tert-butanesulfinyl)imines

The reaction of triorganozincates with (R)-N-(tert-butanesulfinyl) imines gives the expected α-branched sulfinamides in good to excellent yields with diastereomeric ratios of up to 98:2. The N-sulfinyl group of the products can be easily removed by acidic treatment, affording the corresponding chiral primary amines in enantiomeric excesses of up to 96%. The reactivity and the selectivity shown by the triorganozincates are different from the ones observed with the corresponding Grignard reagents, which allows, in several cases, the preparation of both enantiomers of an amine from the same imine substrate. When mixed triorganozincates are used, one can take advantage of the slow transfer rate of the methyl group to use it as a non-transferable one. Both aromatic and aliphatic aldimines, as well as activated ketimines, are good substrates for these addition reactions.

Process for hydrolyzing optically active amides

The present invention relates to a process for hydrolyzing optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, where the hydrolysis of the amides is carried out with an alkali metal or alkalin