114863-90-0Relevant academic research and scientific papers
COMPOUND FOR INHIBITING THE FORMATION OF BETA-AMYLOID FIBRIL, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
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Page/Page column 17, (2008/06/13)
The present invention relates to a novel compound which is effective in inhibiting the formation of beta-amyloid fibril in the brain, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.
Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation
Byeon, Seong Rim,Lee, Ji Hoon,Sohn, Ji-Hoon,Kim, Dong Chan,Shin, Kye Jung,Yoo, Kyung Ho,Mook-Jung, Inhee,Lee, Won Koo,Kim, Dong Jin
, p. 1466 - 1470 (2007/10/03)
New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by Aβ fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activ
