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BOC-L-4-Trifluoromethylphe, also known as N-(tert-Butoxycarbonyl)-4-trifluoromethyl-L-phenylalanine, is a valuable compound in the field of pharmaceuticals and biochemistry. It is a derivative of L-phenylalanine, an essential amino acid, with a trifluoromethyl group substitution at the 4th position and a tert-butoxycarbonyl (BOC) protecting group. BOC-L-4-Trifluoromethylphe is known for its unique properties and potential applications in the development of various pharmaceuticals.

114873-07-3

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114873-07-3 Usage

Uses

Used in Pharmaceutical Industry:
BOC-L-4-Trifluoromethylphe is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its unique structure allows for the development of novel compounds with enhanced properties and improved efficacy.
Used in the Preparation of Ring Substituted Phenylalanines and Tryptophans:
BOC-L-4-Trifluoromethylphe serves as a key building block in the synthesis of ring-substituted phenylalanines and tryptophans. These amino acid derivatives are important components in the development of new drugs and bioactive molecules.
Used in the Preparation of Proline Derivatives:
BOC-L-4-Trifluoromethylphe is also utilized in the preparation of proline derivatives with inhibitory action against dipeptidyl peptidase IV (DPP-IV). DPP-IV inhibitors are of significant interest in the pharmaceutical industry due to their potential in treating type 2 diabetes and other related metabolic disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 114873-07-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,8,7 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 114873-07:
(8*1)+(7*1)+(6*4)+(5*8)+(4*7)+(3*3)+(2*0)+(1*7)=123
123 % 10 = 3
So 114873-07-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H18F3NO4/c1-14(2,3)23-13(22)19-11(12(20)21)8-9-4-6-10(7-5-9)15(16,17)18/h4-7,11H,8H2,1-3H3,(H,19,22)(H,20,21)/t11-/m0/s1

114873-07-3 Well-known Company Product Price

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  • TCI America

  • (B4369)  N-(tert-Butoxycarbonyl)-4-trifluoromethyl-L-phenylalanine  >98.0%(HPLC)(T)

  • 114873-07-3

  • 1g

  • 2,990.00CNY

  • Detail

  • Aldrich

  • (15017)  Boc-Phe(4-CF3)-OH  ≥98.0% (TLC)

  • 114873-07-3

  • 15017-1G

  • 3,602.43CNY

  • Detail

114873-07-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic acid

1.2 Other means of identification

Product number -
Other names N-BOC-4-(Trifluoromethyl)-L-phenylalanine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114873-07-3 SDS

114873-07-3Relevant academic research and scientific papers

N-acylamino acid amide compounds and intermediates for preparation thereof

-

, (2008/06/13)

The present invention discloses the compound represented by the formula (I): wherein A represents the following formula (a-1) or the following formula (a-2): B represents the following formula (b): (wherein the symbols are each as defined in the specification) or a pharmaceutically acceptable salts thereof, and intermediates for the preparation thereof, which have excellent platelet aggregation inhibitory activity and other properties and useful as prophylactic or therapeutic agents for diseases associated with a fibrinogen receptor, thrombosis, infarction and the like.

Studies of Neurokinin Antagonists. 4. Synthesis and Structure-Activity Relationships of Novel Dipeptide Substance P Antagonists: N2--L-prolyl>-N-methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and Its Related Compounds

Hagiwara, Daijiro,Miyake, Hiroshi,Igari, Norihiro,Karino, Masako,Maeda, Yasue,et al.

, p. 2090 - 2099 (2007/10/02)

As an extension of our studies on discovering a novel substance P (SP) antagonist, we modified the previously reported dipeptide, N2-2-(1H-indol-3-ylcarbonyl)-L-lysyl>-N-methyl-N-(phenylmethyl)-L-phenylalaninamide (2b).The lysine part in 2b was first optimized to a (2S,4R)-hydroxyproline derivative (3h), which is 2-fold more potent than 2b in SP binding assay using guinea pig lung membranes.Next we modified the 1H-indol-3-ylcarbonyl part in 3h.Introduction of a methyl group at the indole nitrogen enhanced the oral activity, while retaining the binding activity.Finally, we modified the phenylalanine part to culminate in the most potent compound 7k (FK888), which is a potent SP antagonist with NK1 selectivity as well as oral activity.

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