114886-12-3Relevant academic research and scientific papers
Mild synthesis of N′-aryl-N,N-dimethylformamidinium chloride by Vilsmeier-Haack reagent
Meng, Ge,Sha, Yao Wu,Zhang, Rui,Bai, Nan
experimental part, p. 1043 - 1046 (2012/06/01)
Formamidine derivatives could be used as the building blocks for substituted heterocyclic compounds with various biological activities. N′-Aryl-N,N-dimethylformamidinium chlorides have been synthesized in high yields by reaction of aromatic primary amines with Vilsmeier-Haack reagent at room temperature. The structures of all the new compounds were identified by ESI-MS, IR and NMR spectra. The steric structures of some of these compounds were clarified by X-ray single crystal analysis.
Arylformamidines with Antinociceptive Properties
Gall, M.,McCall, J. M.,TenBrink, R. E.,VonVoigtlander, P. F.,Mohrland, J. S.
, p. 1816 - 1820 (2007/10/02)
A series of formamidines structurally related to clondine were synthesized and investigated as potential nonopiate analgesics.Several of these compounds showed potent analgesic activity (ED50 on HCl writhing 1.0 mg/kg) with low potential for hypotensive effects.A qualitative description of the structure-activity relationship of this series reveals that the 2,4- and 2,6-dimethylphenyl compounds are more potent analgesics than are the corresponding dichlorophenyl compounds.
