1149641-29-1

Basic information

• Product Name: 3-(3-benzyloxy-4-methoxyphenyl)-3-oxo-2-(3,4,5-trimethoxyphenyl)propanenitrile
• Synonyms: 3-(3-benzyloxy-4-methoxyphenyl)-3-oxo-2-(3,4,5-trimethoxyphenyl)propanenitrile
• CAS NO: 1149641-29-1
• Molecular Weight: 447.488
• Mol File: 1149641-29-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3-benzyloxy-4-methoxyphenyl)-3-oxo-2-(3,4,5-trimethoxyphenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-benzyloxy-4-methoxyphenyl)-3-oxo-2-(3,4,5-trimethoxyphenyl)propanenitrile(1149641-29-1)
• EPA Substance Registry System: 3-(3-benzyloxy-4-methoxyphenyl)-3-oxo-2-(3,4,5-trimethoxyphenyl)propanenitrile(1149641-29-1)

Safety Data

• Hazardous Substances Data: 1149641-29-1(Hazardous Substances Data)

Upstream product

• 13338-63-1 2-(3,4,5-trimethoxyphenyl)acetonitrile 
• 57535-57-6 methyl 3-(benzyloxy)-4-methoxy-benzoate 

Downstream Products

• 1149641-46-2 3-(3-benzyloxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)isoxazol-5-amine 

Relevant articles and documents

Synthesis and biological evaluation of 3,4-diaryl-5-aminoisoxazole derivatives

A series of cis-restricted 3,4-diaryl-5-aminoisoxazoles have been synthesized and evaluated for their biological activities. Among them, compound 11a and 13a displayed potent cytotoxic activities in vitro against five human cancer cell lines with IC50 values in the low micromolar range and two compounds inhibited tubulin polymerization with IC50 value of 1.8, and 2.1 μM, respectively, similar to that of CA-4. Compound 13a could arrest at the G2/M phase of the cell cycle at the concentration of 0.1 and 1.0 μM and induce apoptosis at 0.1-1.0 μM.