114969-20-9Relevant academic research and scientific papers
A new synthesis of α-fluorovinylsulfones utilizing the Peterson olefination methodology
Asakura, Noriaki,Usuki, Yoshinosuke,Iio, Hideo
, p. 81 - 88 (2007/10/03)
α-Fluoro-α-silyl-substituted sulfones 1 are readily prepared from fluoromethyl phenyl sulfone and the appropriate silyl chloride. The use of TBSCl improves both the stability and yield of 1. Lithium derivatives 4 undergo a smooth Peterson olefination reaction with less-enolizable carbonyl compounds to give moderate to good yields of the expected α-fluorovinylsulfones 6, in some cases with high E-stereoselectivity. One-pot reaction with 4 generated in situ from fluoromethyl phenyl sulfone in tetrahydrofuran (THF) also proceeds smoothly, particularly with aldehydes.
DIETHYL 1-FLUORO-1-PHENYLSULFONYLMETHANEPHOSPHONATE, A VERSATILE AGENT FOR THE PREPARATION OF MONOFLUORINATED BUILDING BLOCKS
Koizumi, Toru,Hagi, Toru,Horie, Yoshiharu,Takeuchi, Yoshio
, p. 3959 - 3962 (2007/10/02)
Diethyl 1-fluoro-1-phenylsulfonylmethanephosphonate was prepared and was transformed into 1-fluoroalkanephosphonate and phenyl 1-fluorovinyl sulfones, which are useful monofluorinated building blocks.KEYWORDS - diethyl 1-fluoro-1-phenylsulfonylmethanephosphonate; 1-fluoroalkanephosphonate; 1-fluorovinyl sulfone; monofluorinated building block; cycloaddition; Michael reaction; Emmons-Horner reaction
