114973-36-3Relevant academic research and scientific papers
Novel synthesis method of aromatic 5-chloro-2-fluoro-4-(trifluoromethyl) aniline hydrochloride containing trifluoromethyl intermediate
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, (2018/03/28)
The invention discloses a novel synthesis method of aromatic 5-chloro-2-fluoro-4-(trifluoromethyl) aniline hydrochloride containing a trifluoromethyl intermediate. The method comprises steps as follows: 1) 5-chloro-2-fluoroaniline, elemental iodine and the like are subjected to an iodination reaction in an anhydrous ethanol solution; 2) with dichloromethane as a solvent, an obtained aromatic iodination product is subjected to an acetylation reaction; 3) the aromatic iodination product protected by acetyl, methyl fluorosulphonyldifluoroacetate and the like are subjected to a trifluoromethylation reaction at the temperature of 80 DEG C; 4) finally, 6 mol/L hydrochloric acid is used for a deacetylation reaction in ethanol, and a target product is obtained. The novel synthesis method has the advantages that the route design is novel, the product purity is good and operation is safe, simple and convenient; all reactions are stably conducted in the solvent, the process is easy to control, few crude product impurities exist, purification is easy, and the quality and yield of the product are increased. The total yield of the route is 66%, the product purity can reach 98.5%, and the novel synthesis method has higher research and development application value.
A benzoylurea derivative and its production and use
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, (2008/06/13)
A benzoylurea derivative represented by the formula, wherein R1 is a hydrogen atom or a fluorine atom, R2 is a trifluoromethyl group, a pentafluoroethyl group or a heptafluoropropyl group, and R3 is a hydrogen atom, a fluo
