114980-23-3

Basic information

• Product Name: 3,5-DIMETHOXY-THIOBENZAMIDE
• Synonyms: 3,5-DIMETHOXY-THIOBENZAMIDE;Benzenecarbothioamide, 3,5-dimethoxy- (9CI)
• CAS NO: 114980-23-3
• Molecular Formula: C₉H₁₁NO₂S
• Molecular Weight: 197.25
• Product Categories: THIOAMIDE;Substituted Boronic Acids
• Mol File: 114980-23-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 352.1 °C at 760 mmHg
• Flash Point: 166.8 °C
• Appearance: /
• Density: 1.202 g/cm³
• Vapor Pressure: 3.92E-05mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 3,5-DIMETHOXY-THIOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIMETHOXY-THIOBENZAMIDE(114980-23-3)
• EPA Substance Registry System: 3,5-DIMETHOXY-THIOBENZAMIDE(114980-23-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 114980-23-3(Hazardous Substances Data)

Usage

General Description

3,5-DIMETHOXY-THIOBENZAMIDE is a chemical compound that belongs to the class of thiobenzamides. It is a white to off-white solid that is often used in research and pharmaceutical applications. 3,5-DIMETHOXY-THIOBENZAMIDE is known for its thioether and amide functional groups, which make it useful for various chemical reactions and synthesis processes. The 3,5-dimethoxy substitution on the thiobenzamide core can affect its chemical properties and biological activity. It is important to handle this compound with care due to its potential hazards if not used properly.

InChI:InChI=1/C9H11NO2S/c1-11-7-3-6(9(10)13)4-8(5-7)12-2/h3-5H,1-2H3,(H2,10,13)

Upstream product

• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 17213-58-0 3,5-dimethoxybenzamide 
• 19179-31-8 3,5-dimethoxy-benzonitrile 

Downstream Products

• 1097110-19-4 C₁₂H₁₁NO₄S 
• 1332459-59-2 C₃₈H₅₂N₂O₇S₂ 
• 1332459-45-6 C₁₄H₁₅NO₄S 
• 71565-97-4 C₁₀H₁₁N₃O₂ 
• 1333153-04-0 C₁₀H₁₃NO₂S 
• 1221822-60-1 2-(3,5-dimethoxyphenyl)-4H-3,1-benzothiazine 
• 1186493-24-2 2-(3,5-dimethoxyphenyl)thiazole 
• 1013621-95-8 2-(3,5-dimethoxyphenyl)thiazole-4,5-dione 
• 74466-95-8 5-(3,5-Dimethoxy-phenyl)-3-methyl-[1,2,4]thiadiazole 
• 74466-91-4 5-(3,5-Dimethoxy-phenyl)-[1,2,4]thiadiazole 
• 74466-80-1 N-[1-Dimethylamino-meth-(E)-ylidene]-3,5-dimethoxy-thiobenzamide 
• 74466-84-5 N-[1-Dimethylamino-eth-(E)-ylidene]-3,5-dimethoxy-thiobenzamide 

Relevant articles and documents

Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

The free fatty acid receptor 1 (FFA1/GPR40) has attracted interest as a novel target for the treatment of type 2 diabetes. Several series of FFA1 agonists including TAK-875, the most advanced compound terminated in phase III studies due to concerns about liver toxicity, have been hampered by relatively high molecular weight and lipophilicity. Aiming to develop potent FFA1 agonists with low risk of liver toxicity by decreasing the lipophilicity, the middle phenyl of TAK-875 was replaced by 11 polar five-membered heteroaromatics. Subsequently, systematic exploration of SAR and application of molecular modeling, leads to the identification of compound 44, which was an excellent FFA1 agonist with robustly hypoglycemic effect both in normal and type 2 diabetic mice, low risks of hypoglycemia and liver toxicity even at the twice molar dose of TAK-875. Meanwhile, two important findings were noted. First, the methyl group in our thiazole series occupied a small hydrophobic subpocket which had no interactions with TAK-875. Furthermore, the agonistic activity revealed a good correlation with the dihedral angle between thiazole core and the terminal benzene ring. These results promote the understanding of ligand-binding pocket and might help to design more promising FFA1 agonists.

NUCLEAR TRANSPORT MODULATIORS AND USES THEREOF

The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g

Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: Synthesis and structure-activity relationships

Neutrophils have an important role in the self-defense systems of organisms through the production of superoxide. On the other hand, it has been proposed that abnormal amounts of superoxide produced by neutrophils are a serious factor in tissue injury. A series of novel thiazole derivatives was prepared and evaluated inhibitory effect on superoxide production by human neutrophils in vitro. Among these compounds, 6-[2-(3,4- diethoxyphenyl)thiazol-4-yl]-pyridine-2-carboxylic acid (OPC-6535) was selected as one of the most promising compounds. The synthesis and structure- activity relationships of these compounds are reported herein.