114990-90-8

Basic information

• Product Name: (S)-GLYCIDIC ACID
• Synonyms: (S)-GLYCIDIC ACID;(2S)-OXIRANE-2-CARBOXYLIC ACID;(S)-oxirane-2-carboxylic acid
• CAS NO: 114990-90-8
• Molecular Formula: C3H4O3
• Molecular Weight: 88.06
• Mol File: 114990-90-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-GLYCIDIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-GLYCIDIC ACID(114990-90-8)
• EPA Substance Registry System: (S)-GLYCIDIC ACID(114990-90-8)

Safety Data

• Hazardous Substances Data: 114990-90-8(Hazardous Substances Data)

Usage

General Description

(S)-GLYCIDIC ACID is a chemical compound with the molecular formula C3H4O4. It is a chiral molecule, with two enantiomers: (S)-GLYCIDIC ACID and (R)-GLYCIDIC ACID. The (S)-GLYCIDIC ACID is commonly used as a chiral building block in the synthesis of pharmaceuticals and various other organic compounds. It is also used in the production of polymers and as a reagent in organic synthesis. (S)-GLYCIDIC ACID has a wide range of applications in the chemical industry, making it a valuable compound for various manufacturing processes.

Upstream product

• 145937-64-0 (R)-serine ethyl ester 
• 4538-50-5 methyl (2S)-glycidate 
• 60456-23-7 (S)-oxiranemethanol 
• 57044-25-4 (R)-oxiranemethanol 

Downstream Products

• 7417-65-4 (S)-2-hydroxy-3-(1H-indol-3-yl)-propionic acid 

Relevant articles and documents

EFFICIENT SYNTHESES OF ENANTIOMERICALLY PURE L AND D-ALLOTHREONINES AND (S) AND (R) ISOSERINES

Both enantiomers of (S) 1 and (R) 2 isoserine as well (D) 3 and (L) 4 allothreonine are prepared optically pure in three steps by asymmetric Sharpless epoxidation of crotyl and allylic alcohols into 7-10 followed by an improved RuCl3/NaIO4/water oxidation procedure to low molecular weight glycidic acids 11-14 and epoxide opening by ammonia with (20-33 percent) overall yields.

SARS-COV-2 INHIBITORS HAVING COVALENT MODIFICATIONS FOR TREATING CORONAVIRUS INFECTIONS

Provided herein are compounds, pharmaceutical compositions and methods for treating a SARS-CoV-2 infection.

Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin

A series of hybrid compounds of bestatin (1) and actinonin (3), which promote degradation of cellular inhibitor of apoptosis protein 1 (cIAP1), were designed and synthesized. Structure-activity relationship studies indicated that absolute configuration, hydrophobicity at the α-position of the internal amide carbonyl group, and the presence of a small substituent at the α-position of the ester group are important factors for the expression of potent cIAP1 degradation-promoting activity. HAB-5A (30b) showed the most potent activity (IC50 = 0.53 μM) among the compounds prepared.