114990-91-9

Upstream product

• 88319-43-1 (R)-2-amino-4,4-dimethylpentanoic acid 

Downstream Products

• 1201686-90-9 (3S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-2-[(2R)-2-hydroxy-4,4-dimethylpentanoyl]isoxazolidine-3-carboxamide 
• 1097134-08-1 (1S,5R)-N-[[5-chloro-2-(tetrazol-1-yl)phenyl]methyl]-2-[(2R)-2-hydroxy-4,4-dimethylpentanoyl]-2-azabicyclo[3.1.0]hexane-1-carboxamide 
• 1097133-19-1 (1S,2S,5R)-3-((R)-2-hydroxy-4,4-dimethylpentanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide 
• 1097133-17-9 (1S,3S,5S)-2-((R)-2-hydroxy-4,4-dimethylpentanoyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide 
• 1097133-15-7 (1R,3S,5R)-2-((R)-2-hydroxy-4,4-dimethylpentanoyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide 
• 1201686-58-9 (5S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-1-[(2R)-2-hydroxy-4,4-dimethylpentanoyl]-4,5-dihydro-1H-pyrazole-5-carboxamide 
• 1201686-98-7 (3S)-N-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]-2-[(2R)-2-hydroxy-4,4-dimethylpentanoyl]pyrazolidine-3-carboxamide 

Relevant academic research and scientific papers

New Aza-Bicyclohexane Compounds Useful As Inhibitors Of Thrombin

This invention relates to novel pharmaceutically useful compounds of formula (I), in particular compounds that are competitive inhibitors of trypsin-like serine proteases, especially thrombin, their use as medicaments, pharmaceutical compositions containi

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e.g. 1-(3(S)-Cyclopropyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide, and 1-(3-Cyclopropyl-3-methyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide.

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e.g. 1-(3(S)-Cyclopropyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide, and 1-(3-Cyclopropyl-3-methyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide.