1150106-13-0Relevant academic research and scientific papers
Design and synthesis of inhibitors of hedgehog signaling based on the alkaloid cyclopamine
Winkler, Jeffrey D.,Isaacs, Andre,Holderbaum, Laura,Tatard, Valerie,Dahmane, Nadia
, p. 2824 - 2827 (2009)
The synthesis and biological evaluation of structurally simplified, metabolically stable cyclopamine-like Sonic Hedgehog (SHH) signaling inhibitors, i.e., 5, is described in four chemical steps from commercially available steroidal precursors. Biological
STEROID-DERIVED CYCLOPAMINE ANALOGS AND METHODS FOR USING THE SAME IN THE PREVENTION OR TREATMENT OF CANCER
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Page/Page column 10; 28, (2009/06/27)
The present invention relates to steroid-derived cyclopamine analogs and methods for using the same for inhibiting sonic hedgehog signaling and preventing or treating cancer. A method for synthesizing the analogs of the present invention from a steroid is also provided.
