1150106-18-5Relevant academic research and scientific papers
Studies directed toward the elucidation of the pharmacophore of steroid-based sonic hedgehog signaling inhibitors
Isaacs, Andre K.,Xiang, Chaomei,Baubet, Valerie,Dahmane, Nadia,Winkler, Jeffrey D.
supporting information; experimental part, p. 5140 - 5143 (2011/12/15)
Previous work from our laboratory has established that the readily available steroid-based analog 2 of cyclopamine 1 is, like 1, a highly potent inhibitor of Hedgehog signaling. The first structure-activity relationship studies on 2, i.e., the synthesis and biological evaluation of both the C-17 epi analog 4 and the C-3 deoxy analog 11, both of which are more potent than cyclopamine 1, are described. The implications of these results for the emerging pharmacophore of these Sonic Hedgehog signaling inhibitors are discussed.
STEROID-DERIVED CYCLOPAMINE ANALOGS AND METHODS FOR USING THE SAME IN THE PREVENTION OR TREATMENT OF CANCER
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Page/Page column 29, (2009/06/27)
The present invention relates to steroid-derived cyclopamine analogs and methods for using the same for inhibiting sonic hedgehog signaling and preventing or treating cancer. A method for synthesizing the analogs of the present invention from a steroid is also provided.
