1150248-69-3Relevant academic research and scientific papers
Liver X receptor agonists with selectivity for LXRβ; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides
Swahn, Britt-Marie,Macsari, Istvan,Viklund, Jenny,Oehberg, Liselotte,Sjoedin, Johanna,Neelissen, Jan,Lindquist, Johanna
scheme or table, p. 2009 - 2012 (2009/11/30)
The synthesis and SAR of a new series of LXR agonist is reported. The N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamide hits were found in a limited screen of the AstraZeneca compound collection. The effort to optimize these hits into LXRβ selectivity is described. Compound 20 displayed desirable pharmacokinetic profile and up regulation of ABCA1 and ABCG1 mRNA in the brain were achieved when evaluated in vivo in mice.
