115026-35-2

Upstream product

• 72669-83-1 (2RS,3RS,5RS)-p-nitrobenzyl 3-ethylthio-7-oxo-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 72669-83-1 (2RS,3RS,5SR)-p-nitrobenzyl 3-ethylthio-7-oxo-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 115026-33-0 p-nitrobenzyl (2RS,3RS,5RS)-3-acetoxy-3-ethylthio-7-oxo-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 115026-33-0 p-nitrobenzyl (2RS,3SR,5SR)-3-acetoxy-3-ethylthio-7-oxo-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 115026-33-0 p-nitrobenzyl (2RS,3SR,5RS)-3-acetoxy-3-ethylthio-7-oxo-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 72669-83-1 (2RS,3SR,5RS)-p-nitrobenzyl 3-ethylthio-7-oxo-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 72669-83-1 (2R,5R)-3-Ethylsulfanyl-7-oxo-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester 
• 115026-34-1 p-nitrobenzyl (2RS,3RS,5RS)-3-acetoxy-3-ethylsulphonyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 115026-34-1 p-nitrobenzyl (2RS,3SR,5RS)-3-acetoxy-3-ethylsulphonyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 

Relevant academic research and scientific papers

Olivanic Acid Analogues. Part 7. Lead Tetra-acetate Oxidation of 3-Alkylthio-7-oxo-1-aza-bicycloheptane-2-carboxylates

Lead tetra-acetate oxidation of alkylthiocarbapenams (2)-(4) gave α-acetoxy sulphides (5)-(7) with inversion of stereochemistry.Iodosobenzene diacetate was also an effective oxidant.Oxidation to sulphone and elimination of alkanesulphinic acid provided th

SYNTHESIS OF THE 3-ACETOXY-7-OXO-1-AZABICYCLOHEPT-2-ENE-CARBOXYLATE SYSTEM

Lead tetraacetate oxidation of the carbapenem derived ethanethiol adduct (4-6) gave the corresponding 3-acetoxy-3-ethylthio derivatives (7-9).Oxidation to sulphone and elimination of ethylsulphinic acid furnished the 3-acetoxy-7-oxo-1-azabicyclohep