115045-61-9Relevant academic research and scientific papers
Decarboxylative Hydroalkylation of Alkynes
Till, Nicholas A.,Smith, Russell T.,MacMillan, David W. C.
, p. 5701 - 5705 (2018)
The merger of open- and closed-shell elementary organometallic steps has enabled the selective intermolecular addition of nucleophilic radicals to unactivated alkynes. A range of carboxylic acids can be subjected to a CO2 extrusion, nickel capture, migratory insertion sequence with terminal and internal alkynes to generate stereodefined functionalized olefins. This platform has been further extended, via hydrogen atom transfer, to the direct vinylation of unactivated C-H bonds. Preliminary studies indicate that a Ni-alkyl migratory insertion is operative.
Construction of C-C Bond via C-N and C-O Cleavage
He, Rong-De,Pang, Xiaobo,Shu, Xing-Zhong
, p. 635 - 640 (2020/04/07)
The construction of a C-C bond is a center subject in synthetic organic chemistry. The cross-electrophile coupling has provided a powerful tool to forge the C-C bond. However, this process generally requires organic halides, which has severely restricted
Synthesis of 1,1-Disubstituted Ethenes by Means of Sequential Cross-Coupling Reactions
Fiandanese, V.,Marchese, G.,Naso, F.,Ronzini, L.
, p. 1034 - 1036 (2007/10/02)
A variety of 1-alkenes are synthesized in 63-91percent yields by means of sequential cross-coupling reactions of Grignard reagents with readily available or commercial starting materials, in the presence of transition-metal catalysts.
