H-Asn-AMC, also known as N-acetyl-L-asparagine methyl coumaryl-7-amide, is a synthetic chemical compound widely utilized in biological research and drug development. It serves as a substrate analog for asparagine-specific proteases, such as legumain, and is particularly effective in fluorogenic assays due to its ability to release a fluorescent product upon enzymatic cleavage. This property makes H-Asn-AMC an indispensable tool for studying the functions and mechanisms of various proteases, as well as identifying potential therapeutic targets for diseases characterized by dysregulated protease activity.
115047-89-7
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Basic information
- Product Name: H-Asn-AMC
- Synonyms: H-Asn-AMC;H-Asn-AMC Trifluoroacetate salt
- CAS NO:115047-89-7
- Molecular Formula: C14H15N3O4
- Molecular Weight: 289.2866
- EINECS: N/A
- Product Categories: N/A
- Mol File: 115047-89-7.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: H-Asn-AMC(CAS DataBase Reference)
- NIST Chemistry Reference: H-Asn-AMC(115047-89-7)
- EPA Substance Registry System: H-Asn-AMC(115047-89-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 115047-89-7(Hazardous Substances Data)
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115047-89-7 Usage
Uses
Used in Enzyme Assays:H-Asn-AMC is used as a substrate in enzyme assays for the detection and quantification of asparagine-specific proteases. Its fluorescent properties upon enzymatic cleavage allow for the measurement of protease activity, providing valuable insights into the functions and mechanisms of these enzymes.
Used in Drug Development:
In the pharmaceutical industry, H-Asn-AMC is employed as a crucial tool in drug development studies. Its ability to interact with asparagine-specific proteases makes it a valuable asset in the identification of potential therapeutic targets for diseases involving dysregulated protease activity. By understanding the interactions between H-Asn-AMC and these proteases, researchers can develop more effective treatments for such conditions.
Used in Research Studies:
H-Asn-AMC is extensively used in research studies across various scientific disciplines, including biochemistry, molecular biology, and cell biology. Its role as a substrate analog for asparagine-specific proteases enables researchers to investigate the roles of these enzymes in various biological processes and disease pathways. This knowledge can contribute to the development of novel therapeutic strategies and a deeper understanding of the underlying mechanisms of various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 115047-89-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,0,4 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.Calculate Digit Verification of CAS Registry Number 115047-89:
(8*1)+(7*1)+(6*5)+(5*0)+(4*4)+(3*7)+(2*8)+(1*9)=107
107 % 10 = 7
So 115047-89-7 is a valid CAS Registry Number.
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H-Asn-AMC
