115050-50-5

Upstream product

• 585-71-7 (1-bromoethyl)benzne 
• 2609-49-6 diethyl p-nitrobenzylphosphonate 
• 74-88-4 methyl iodide 
• 33973-48-7 diethyl (1-phenylethyl)phosphonate 

Downstream Products

• 1132937-18-8 (E)-N-(4-(1-(3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxyphenyl)prop-1-en-2-yl)phenyl)methanesulfonamide 
• 1132945-36-8 (E)-1-(3-(tert-butyl)-4-methoxy-5-(2-(4-nitrophenyl)prop-1-en-1-yl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione 
• 1206775-01-0 5-bromo-1-tert-butyl-2-methoxy-3-[(E)-2-(4-nitro-phenyl)-propenyl]-benzene 
• 5470-45-1 (1-{4-[bis-(2-iodo-ethyl)-amino]-phenyl}-ethyl)-phosphonic acid diethyl ester 
• 102873-85-8 (1-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-ethyl)-phosphonic acid diethyl ester 
• 856997-52-9 [1-(4-amino-phenyl)-ethyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability

ABT-072 is a non-nucleoside HCV NS5B polymerase inhibitor that was discovered as part of a program to identify new direct-acting antivirals (DAAs) for the treatment of HCV infection. This compound was identified during a medicinal chemistry effort to impr

Efficient synthesis of α-substituted ethylphosphonates via CuH-catalyzed conjugate reduction of terminal alkenylphosphonate

An unprecedented approach toward synthesis of α-substituted ethylphosphonates based on CuH-catalyzed conjugate reduction of vinylphosphonates has been successfully developed. This protocol features mild conditions, broad substrate scope, good functional group compatibility, high overall efficiencies, and easy gram-scale synthesis. The Cu-catalyzed reduction takes place in a highly selective manner on the phosphono substituted C[dbnd]C bond in the case of the reaction of alkenylphosphonates bearing both phosphono and alkyl or aryl substituted alkene moieties. Furthermore, the result of competitive reaction indicates that the Cu-catalyzed conjugate reduction of vinylphosphonate is more challenging and reproducible than the corresponding acrylate's reaction.

Metal-free diimide reduction of alkenylphosphonates: simple and efficient protocol for the synthesis of α-substituted ethylphosphonates

A simple and straightforward method for the synthesis of α-substituted ethylphosphonates via diimide reduction strategy is described. With K3PO4 or Na2CO3 as the basic additive, a range of terminal alkenylphosph