1150561-08-2Relevant academic research and scientific papers
Reaction of indoles with aromatic fluoromethyl ketones: An efficient synthesis of trifluoromethyl(indolyl)phenylmethanols using K2CO3/n-Bu4PBr in water
Pillaiyar, Thanigaimalai,Sedaghati, Masoud,Schnakenburg, Gregor
supporting information, p. 778 - 7490 (2020/05/18)
A new, mild and efficient protocol for the synthesis of trifluoromethyl(indolyl)phenylmethanols by the reaction of indoles with a variety of aromatic fluoromethyl ketones in the presence of K2CO3 (15 mol %) and n-Bu4PBr (15 mol %) in water. The desired products were obtained in good to excellent yields without requiring a column chromatographic purification. The reusability of the catalytic system and large-scale synthesis of indolyl(phenyl)methanols, which would further transform into biological active indole-derived compounds, are further advantages of this protocol.
Efficient guanidine-catalyzed alkylation of indoles with fluoromethyl ketones in the presence of water
Bandini, Marco,Sinisi, Riccardo
supporting information; experimental part, p. 2093 - 2096 (2009/09/30)
A simple and efficient guanidine-catalyzed methodology for the direct preparation of trifluoromethyl-indolyl-phenylethanols in the presence of water is reported. This synthetically viable class of compounds is obtained in excellent yields (up to 98%) thro
