115059-27-3Relevant academic research and scientific papers
A convenient one-pot synthesis of 4-methyl-3-phenyl-, 3-aryl- and 3-aryl-4-phenylcoumarins
Kamat, Shrivallabh P.,D'Souza, Asha M.,Paknikar, Shashikumar K.,Beauchamp, Philip S.
, p. 242 - 246 (2007/10/03)
Thermal condensation of 2′-hydroxyacetophenones 1a-e with phenylacetic acid 2a in refluxing diphenyl ether gives 4-methyl-3-phenylcoumarins 3a-e. Similarly, reaction of 2-hydroxybenzaldehydes 1f-m and 2-hydroxybenzo-phenones 1n-p with phenylacetic acids 2a-d gives the corresponding 3-arylcoumarins 3f-m and 3-aryl-4-phenylcoumarins 3n-p respectively. Formation of esters 4 and 5 and benzofuran 6 is also observed.
A General Synthesis of 3,4-Disubstituted Coumarins
Patil, Vinayak O.,Kelkar, Shriniwas L.,Wadia, Murzban S.
, p. 674 - 675 (2007/10/02)
The complex of POCl3 and the substituted N,N-diethylacetamide is condensed with substituted o-hydroxy-acetophenones and -benzophenones to afford 3,4-disubstituted coumarins (1a-k).
