1150641-83-0Relevant academic research and scientific papers
Exploring the PI3Kα and γ binding sites with 2,6-disubstituted isonicotinic derivatives
Cherian, Philip T.,Koikov, Leonid N.,Wortman, Matthew D.,Knittel, James J.
scheme or table, p. 2215 - 2219 (2009/12/07)
A homology model of the p110α catalytic subunit of PI3Kα was generated from the p110γ crystal structure. Using this model, an isonicotinic scaffold was designed for chemically exploring the PI3Kα and γ binding sites. A focused library of derivatives was s
