1150656-69-1Relevant academic research and scientific papers
Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors
Tsai, Ting-Yueh,Hsu, Tsu,Chen, Chiung-Tong,Cheng, Jai-Hong,Chiou, Mei-Chun,Huang, Chih-Hsiang,Tseng, Ya-Ju,Yeh, Teng-Kuang,Huang, Chung-Yu,Yeh, Kai-Chia,Huang, Yu-Wen,Wu, Ssu-Hui,Wang, Min-Hsien,Chen, Xin,Chao, Yu-Sheng,Jiaang, Weir-Torn
scheme or table, p. 1908 - 1912 (2009/11/30)
A series of (2S)-cyanopyrrolidines with glutamic acid derivatives at the P2 site have been prepared and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV). The structure-activity relationships (SAR) led to the discovery of potent 3-substituted glutamic acid analogues, providing enhanced chemical stability and excellent selectivity over the closely related enzymes, DPP8, DPP-II and FAP. Compound 13f exhibited the ability to both significantly decrease the glucose excursion and inhibit plasma DPP-IV activity.
