1150697-95-2Relevant academic research and scientific papers
Bicyclic tetrapeptides as potent HDAC inhibitors: Effect of aliphatic loop position and hydrophobicity on inhibitory activity
Islam, Md. Nurul,Islam, Md. Shahidul,Hoque, Md. Ashraful,Kato, Tamaki,Nishino, Norikazu,Ito, Akihiro,Yoshida, Minoru
, p. 3862 - 3870 (2014)
Several histone deacetylase (HDAC) inhibiting bicyclic tetrapeptides have been designed and synthesized through intramolecular ring-closing metathesis (RCM) reaction and peptide cyclization. We designed bicyclic tetrapeptides based on CHAP31, trapoxin B a
Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors
Suzuki, Nobuaki,Suzuki, Takayoshi,Ota, Yosuke,Nakano, Tatsuya,Kurihara, Masaaki,Okuda, Haruhiro,Yamori, Takao,Tsumoto, Hiroki,Nakagawa, Hidehiko,Miyata, Naoki
experimental part, p. 2909 - 2922 (2010/01/16)
Guided by the proposed catalytic mechanism of histone deacetylases (HDACs), we designed and synthesized a series of boronic acid-based HDAC inhibitors bearing an R-amino acid moiety. In this series, compounds (S)-18, 20, and 21 showed potent HDAC-inhibito
