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1150883-75-2

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  • (aS,2S,3R)-5-Carboxy-4-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-3,4-dihydro-a-[(1R)-1-hydroxyethyl]-3-methyl-2H-pyrrole-2-acetic Acid

    Cas No: 1150883-75-2

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1150883-75-2 Usage

Uses

(αS,2S,3R)-5-Carboxy-4-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-3,4-dihydro-α-[(1R)-1-hydroxyethyl]-3-methyl-2H-pyrrole-2-acetic Acid is an impurity of Ertapenem (E635000).

Check Digit Verification of cas no

The CAS Registry Mumber 1150883-75-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,0,8,8 and 3 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1150883-75:
(9*1)+(8*1)+(7*5)+(6*0)+(5*8)+(4*8)+(3*3)+(2*7)+(1*5)=152
152 % 10 = 2
So 1150883-75-2 is a valid CAS Registry Number.

1150883-75-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R)-2-[(1R,2R)-1-carboxy-2-hydroxypropyl]-4-[(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1150883-75-2 SDS

1150883-75-2Upstream product

1150883-75-2Downstream Products

1150883-75-2Relevant articles and documents

A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation

Lohans, Christopher T.,van Groesen, Emma,Kumar, Kiran,Tooke, Catherine L.,Spencer, James,Paton, Robert S.,Brem, Jürgen,Schofield, Christopher J.

, p. 1282 - 1285 (2018)

β-Lactamases threaten the clinical use of carbapenems, which are considered antibiotics of last resort. The classical mechanism of serine carbapenemase catalysis proceeds through hydrolysis of an acyl-enzyme intermediate. We show that class D β-lactamases also degrade clinically used 1β-methyl-substituted carbapenems through the unprecedented formation of a carbapenem-derived β-lactone. β-Lactone formation results from nucleophilic attack of the carbapenem hydroxyethyl side chain on the ester carbonyl of the acyl-enzyme intermediate. The carbapenem-derived lactone products inhibit both serine β-lactamases (particularly class D) and metallo-β-lactamases. These results define a new mechanism for the class D carbapenemases, in which a hydrolytic water molecule is not required.

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