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5-(N-methyl-N-propyl)amiloride, also known as 5-N-methyl-N-propyl-amiloride, is a chemical compound with the molecular formula C12H24N2O. It is a derivative of amiloride, a potassium-sparing diuretic used to treat hypertension and congestive heart failure. This specific compound is characterized by the presence of a methyl and propyl group attached to the nitrogen atom in the amiloride structure. It is primarily used in scientific research to study the effects on ion transport and membrane potential, particularly in the context of sodium and potassium channels. The compound is known for its ability to inhibit the epithelial sodium channel (ENaC), which plays a crucial role in the regulation of sodium and fluid balance in the body. Its application in research helps to understand the mechanisms underlying various physiological and pathological conditions related to ion transport.

1151-75-3

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1151-75-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1151-75-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,5 and 1 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1151-75:
(6*1)+(5*1)+(4*5)+(3*1)+(2*7)+(1*5)=53
53 % 10 = 3
So 1151-75-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H16ClN7O/c1-3-4-18(2)8-6(11)15-5(7(12)16-8)9(19)17-10(13)14/h3-4H2,1-2H3,(H2,12,16)(H4,13,14,17,19)

1151-75-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name MPA

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:1151-75-3 SDS

1151-75-3Downstream Products

1151-75-3Relevant academic research and scientific papers

Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3)

Kuduk, Scott D.,Di Marco, Christina N.,Chang, Ronald K.,DiPardo, Robert M.,Cook, Sean P.,Cato, Matthew J.,Jovanovska, Aneta,Urban, Mark O.,Leitl, Michael,Spencer, Robert H.,Kane, Stefanie A.,Bilodeau, Mark T.,Hartman, George D.,Bock, Mark G.

scheme or table, p. 2514 - 2518 (2009/12/25)

A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.

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