115102-84-6 Usage
Uses
Used in Pharmaceutical Industry:
2-Sulfanilamido-3-oxopyrazine is used as an impurity in the synthesis of Sulfamethoxypyrazine (S699230), an antimalarial drug. Its presence in the synthesis process is crucial for the development of the final product, which is effective in treating malaria.
Used in Antimalarial Applications:
As an impurity in the synthesis of Sulfamethoxypyrazine, 2-Sulfanilamido-3-oxopyrazine contributes to the development of an antimalarial drug that targets and eliminates the Plasmodium parasite responsible for causing malaria. This application is significant in combating the global health issue of malaria, which affects millions of people worldwide.
Used in Necroptosis Inhibitor Synthesis:
2-Sulfanilamido-3-oxopyrazine is also used in the synthesis of necrosulfonamide, a necroptosis inhibitor. Necroptosis is a form of programmed cell death that can be targeted for therapeutic purposes in various diseases. The compound's role in the synthesis of necrosulfonamide highlights its potential in developing novel treatments for conditions where necroptosis plays a significant role.
Check Digit Verification of cas no
The CAS Registry Mumber 115102-84-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,1,0 and 2 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 115102-84:
(8*1)+(7*1)+(6*5)+(5*1)+(4*0)+(3*2)+(2*8)+(1*4)=76
76 % 10 = 6
So 115102-84-6 is a valid CAS Registry Number.
115102-84-6Relevant academic research and scientific papers
Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein
Liao, Daohong,Sun, Liming,Liu, Weilong,He, Sudan,Wang, Xiaodong,Lei, Xiaoguang
, p. 333 - 337 (2014/03/21)
Through high-throughput screening of 200000 compounds and subsequent structure-activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small molecule inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z). Applying a forward chemical genetic approach, we utilized an NSA based chemical probe to further reveal that NSA selectively targeted the Mixed Lineage Kinase Domain-like Protein (MLKL) to block the necrosome formation.
