115102-84-6

Basic information

• Product Name: 2-Sulfanilamido-3-oxopyrazine
• Synonyms: 2-Sulfanilamido-3-oxopyrazine
• CAS NO: 115102-84-6
• Molecular Weight: 266.28
• Mol File: 115102-84-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Sulfanilamido-3-oxopyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Sulfanilamido-3-oxopyrazine(115102-84-6)
• EPA Substance Registry System: 2-Sulfanilamido-3-oxopyrazine(115102-84-6)

Safety Data

• Hazardous Substances Data: 115102-84-6(Hazardous Substances Data)

Usage

Uses

4-Amino-?N-?(3,?4-?dihydro-?3-?oxo-?2-?pyrazinyl)?benzenesulfonamide is an impurity of Sulfamethoxypyrazine (S699230), an antimalarial, and used in the synthesis of necrosulfonamide, a necroptosis inhibitor.

Upstream product

• 152-47-6 Sulfalen 

Downstream Products

• 1384274-38-7 (E)-N-(4-(N-(3-hydroxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 

Relevant articles and documents

Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein

Through high-throughput screening of 200000 compounds and subsequent structure-activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small molecule inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z). Applying a forward chemical genetic approach, we utilized an NSA based chemical probe to further reveal that NSA selectively targeted the Mixed Lineage Kinase Domain-like Protein (MLKL) to block the necrosome formation.