115134-60-6

Usage

Uses

Used in Organic Synthesis:
2-(bromomethyl)-4-chloro-1-isothiocyanatobenzene is used as a reagent in organic synthesis for the preparation of various organic compounds. Its unique functional groups allow for versatile reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-(bromomethyl)-4-chloro-1-isothiocyanatobenzene is used as a key intermediate in the synthesis of drugs. Its presence in the molecular structure can contribute to the biological activity of the final product, making it an essential component in the development of new medications.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical sector, 2-(bromomethyl)-4-chloro-1-isothiocyanatobenzene is utilized as a precursor in the production of agrochemicals. Its reactive functional groups can be incorporated into the structures of pesticides or other agricultural chemicals to enhance their effectiveness in protecting crops and controlling pests.
Used in Research and Development:
2-(bromomethyl)-4-chloro-1-isothiocyanatobenzene is also employed in research and development settings, where its reactivity and structural features are explored for potential applications in new chemical processes or the discovery of novel compounds with specific properties.

Upstream product

• 23165-53-9 4-chloro-2-methylphenyl isothiocyanate 

Downstream Products

• 115134-73-1 5-chloro-2-isothiocyanatobenzyltriphenylphosphonium bromide 

Relevant academic research and scientific papers

Heterocyclic compounds for treating myocardial ischemia

PCT No. PCT/FR96/01176 Sec. 371 Date Jan. 26, 1998 Sec. 102(e) Date Jan. 26, 1998 PCT Filed Jul. 25, 1996 PCT Pub. No. WO97/05134 PCT Pub. Date Feb. 13, 1997Substituted N-heterocyclyl-1-aryloxyalkyl-4-piperldineamines of formula (I) wherein each of R1 to R4, which are the same or different, is hydrogen, optionally branched C1-4 alkyl, optionally branched C1-4 alkyloxy, halo, nitro, hydroxy, or trifluoromethyl or trifluoromethoxyl; R5 is hydrogen, optionally branched C1-6 alkyl, optionally branched C7-12 phenylalkyl optionally substituted on the phenyl by one or more radicals having the same definition as R1; W and X are oxygen or sulphur; Y is C2-6 polymethylene or -CH2-CH(OH)-CH2-; and n is 0 or 1; and pure R or S isomers of said compounds, where applicable, as well as mixtures thereof, as well as therapeutically-acceptable organic or inorganic salts and hydrates of the compounds and a method for preparing the compounds and their use as drugs are all disclosed.

2-ISOTHIOCYANATOBENZYLTRIPHENYLPHOSPHONIUM BROMIDES - NEW TYPE OF FUNCTIONALIZED HETEROCUMULENES SUITABLE FOR SYNTHESIS OF INDOLE DERIVATIVES

Reaction of 2-bromomethylphenyl isothiocyanates with triphenylphosphine afforded triphenyl-(2-isothiocyanatobenzyl)phosphonium salts.Their reaction with bases liberated the corresponding carbanions which on intramolecular addition to the N=C=S group gave substituted 3-triphenylphosphoniumindolyl-2-thiolates.These compounds did not react in the Wittig reaction but underwent electrophilic reactions on the sulfur atom or the indol nitrogen atom.According to a detailed analysis of 1H, 13C, 31P NMR and mass spectra, the indole derivatives exist predominantly in the betaine form.X-Ray diffraction analysis of the unsubstituted betaine, 3-triphenylphosphoniumindolyl-2-thiolate, agrees well with the spectral results.