1151513-23-3Relevant academic research and scientific papers
Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis
Browne, Lorcan,Lidster, Katie,Al-Izki, Sarah,Clutterbuck, Lisa,Posada, Cristina,Chan, A. W. Edith,Riddall, Dieter,Garthwaite, John,Baker, David,Selwood, David L.
supporting information, p. 2942 - 2952 (2014/05/06)
A series of imidazol-1-ylethylindazole sodium channel ligands were developed and optimized for sodium channel inhibition and in vitro neuroprotective activity the molecules exhibited displacement of a radiolabeled sodium channel ligand and selectivity for blockade of the inactivated state of cloned neuronal Nav channels. Metabolically stable analogue 6 was able to protect retinal ganglion cells during optic neuritis in a mouse model of multiple sclerosis.
Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones
Clutterbuck, Lisa A.,Posada, Cristina Garcia,Visintin, Cristina,Riddall, Dieter R.,Lancaster, Barrie,Gane, Paul J.,Garthwaite, John,Selwood, David L.
supporting information; experimental part, p. 2694 - 2707 (2010/03/03)
We report the discovery of a new class of neuroprotective voltage-dependent sodium channel modulators exemplified by (5-(1-benzyl-1H-indazol-3-yl)-1,2,4- oxadiazol-3-yl)methanamine 11 (CFM1178). The compounds were inhibitors of [ 14C]guanidiniu
