115156-63-3

Basic information

• Product Name: (R)-Hydroxy-naphthalen-1-yl-phenyl-acetic acid
• CAS NO: 115156-63-3
• Molecular Weight: 278.307
• Mol File: 115156-63-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-Hydroxy-naphthalen-1-yl-phenyl-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Hydroxy-naphthalen-1-yl-phenyl-acetic acid(115156-63-3)
• EPA Substance Registry System: (R)-Hydroxy-naphthalen-1-yl-phenyl-acetic acid(115156-63-3)

Safety Data

• Hazardous Substances Data: 115156-63-3(Hazardous Substances Data)

Upstream product

• 18434-67-8 O-(naphthyl-⁽¹⁾-oxoacetyl)-(1R)-menthol 
• 58635-82-8 (S,S)-2-benzyl-4-methoxymethyl-5-phenyl-2-oxazoline 
• 63007-15-8 trans-(4S,5S)-2-benzoyl-4-(methoxymethyl)-5-phenyl-2-oxazoline 
• 115156-57-5 (2S,4aS,7R,8aR)-2-benzoyl-N-benzyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine 
• 703-55-9 1-naphthylmagnesiumbromide 
• 73698-01-8 ((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-naphthalen-1-yl-phenyl-methanol 
• 1074-12-0 phenylglyoxal hydrate 

Relevant articles and documents

HIGHLY ENANTIOSELECTIVE SYNTHESES OF α-HYDROXYACIDS USING N-BENZYL-4,4,7α-TRIMETHYL-TRANS-OCTAHYDRO-1,3-BENZOXAZINE AS A CHIRAL ADJUVANT

Addition of Grignard and organolithium reagents to as well as hydride reduction of 2α-benzoyl-N-benzyl-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine (2, Y = C6H5CO) and addition of phenylmagnesium bromide to the corresponding 2-acetyl analog (11) proceed in highly diastereoselective fashion to produce virrtually exclusively the diastereomer predicted on the basis of Cram's chelate rule if chelation involves the ring oxygen atom.Mild acid hydrolysis of the adducts followed by selective oxidation produces highly enantiomerically pure α-hydroxyacids with clean recovery of the chiral adjuvant.