1151561-17-9Relevant academic research and scientific papers
Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis
Manzoni, Leonardo,Belvisi, Laura,Potenza, Donatella,Vasile, Francesca,Seneci, Pierfausto,Bianchi, Aldo,Drago, Carmelo,De Matteo, Marilenia,Ferrante, Luca,Scolastico, Carlo,Timpano, Gabriele,Rizzo, Vincenzo,Conti, Annalisa,Perego, Paola,Mastrangelo, Eloise,Servida, Federica
, p. 6687 - 6708,22 (2012/12/12)
Novel pro-apoptotic, homo- and heterodimeric Smac mimetics/IAPs inhibitors based on the N-AVPI-like 4-substituted 1-aza-2-oxobicyclo[5.3.0]decane scaffold were prepared from monomeric structures connected through a head-head (8), tail-tail (9) or head-tail (10) linker. The selection of appropriate decorating functions for the scaffolds, and of rigid and flexible linkers connecting them, is described. The synthesis, purification and analytical characterization of each prepared dimer 8-10 is thoroughly described.
NEW SMAC MIMETIC COMPOUNDS AS APOPTOSIS INDUCERS
-
Page/Page column 116-117, (2009/06/27)
The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of a
