1151652-95-7

Upstream product

• 120450-07-9 2-amino-4-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile 
• 77287-34-4 formamide 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 123148-78-7 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine 
• 1207543-30-3 4‐chloro‐5‐iodo‐7‐((2‐(trimethylsilyl)ethoxy)methyl)‐7H‐pyrrolo[2,3‐d]pyrimidine 
• 1207543-31-4 5-iodo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 

Downstream Products

• 1151651-00-1 5-(4-chloro-phenyl)-7-cyclopropylmethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine 

Relevant academic research and scientific papers

PYRROLOPYRIMIDINES AS CFTR POTENTIATORS

The present invention relates to compounds of Formula I, wherein R1a, R1b, R2, R3, R4, W, Y, and Z are as described herein, and pharmaceutically acceptable salts thereof. The compounds are potentiator

MODULATION OF PROTEIN TRAFFICKING

Compounds and compositions are provided for treatment or amelioration of one or more disorders characterized by defects in protein trafficking. A method of treating a disorder characterized by impaired protein trafficking includes administering to a subject or contacting a cell with a compound of Formula I: [formula here] or pharmaceutically acceptable salts or derivatives thereof.