1151663-71-6Relevant academic research and scientific papers
Novel fatty acid synthase (FAS) inhibitors: Design, synthesis, biological evaluation, and molecular docking studies
Wang, Xiaokui,Lin, Jian,Chen, Yao,Zhong, Wu,Zhao, Guoming,Liu, Hongying,Li, Site,Wang, Lili,Li, Song
, p. 1898 - 1904 (2009)
Several novel series of C75 derivatives were synthesized and evaluated for their FAS inhibitory activities. The results showed compound 4-methylene-2-octyl-5-oxo-tetrahydro-thiophene-3-carboxylic acid (1c) had more effective FAS inhibitory (IC50 was 2.56 μM and T.I. was 9.26) and potent anti-tumor activities on HL60 and Hela cells in vitro (IC50 were 5.38 μM and 46.10 μM, respectively).
