115177-91-8

Upstream product

• 108-96-3 4-pyridone 
• 1885-14-9 phenyl chloroformate 
• 620-08-6 4-methoxypyridine 

Downstream Products

• 138832-06-1 4-Oxo-2-pent-4-enyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester 
• 138832-10-7 (2S,4aR,5R,8aR)-5-Methyl-4-oxo-2-propyl-octahydro-quinoline-1-carboxylic acid phenyl ester 
• 138832-10-7 (2S,4aS,5R,8aR)-5-Methyl-4-oxo-2-propyl-octahydro-quinoline-1-carboxylic acid phenyl ester 
• 138832-07-2 (2R,6S)-4-Oxo-2-pent-4-enyl-6-propyl-piperidine-1-carboxylic acid phenyl ester 
• 138832-07-2 (2R,6R)-4-Oxo-2-pent-4-enyl-6-propyl-piperidine-1-carboxylic acid phenyl ester 
• 138832-11-8 (2R,4aR,5S,8aS)-5-Methyl-2-propyl-4-trifluoromethanesulfonyloxy-4a,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester 
• 138832-08-3 (2R,6S)-4-Oxo-2-(4-oxo-butyl)-6-propyl-piperidine-1-carboxylic acid phenyl ester 
• 138832-09-4 (2S,8aR)-4-Oxo-2-propyl-3,4,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester 

Relevant academic research and scientific papers

N-acyldihydropyridones as synthetic intermediates. A short synthesis of (±)-pumiliotoxin C

A stereocontrolled synthesis of (±)-pumiliotoxin C was achieved from 4-methoxypyridine in seven steps.

RING LITHIATION OF PYRIDONES

Lithiation of 1-methyl-2-pyridone takes place mainly at the methyl group which then leads to a dimer (11) by addition to a second mol equivalent of pyridone at C-6.Lithiation of 1-methyl-4-pyridone takes place cleanly and efficiently at C-2; this lithio d