1151952-76-9Relevant academic research and scientific papers
Nitrogen nucleophiles in au-catalyzed dehydrative cyclization reactions
Ketcham, John M.,Cardoso, Flavio S. P.,Biannic, Berenger,Piras, Henri,Aponick, Aaron
, p. 923 - 931 (2014/05/06)
Mild conditions for the gold-catalyzed dehydrative cyclization of carbamate-protected azaallylic alcohols to form saturated nitrogen heterocycles are reported. The cyclization reactions are high-yielding, operationally easy to perform, and provide heterocycles with a synthetically useful vinyl group, strategically located on the ring system, which can facilitate further transformations for target oriented synthesis. It is also demonstrated through chirality transfer experiments that the mechanism can be either cationic in nature or a Au-catalyzed addition/elimination sequence. The diverging mechanistic scenario is dependent on the nature of the substituents on the allylic alcohol and necessitates judicious substrate design.
Palladium-catalyzed intramolecular hydroamination of allenes coupled to aerobic alcohol oxidation
Qiu, Shuifa,Wei, Yunyang,Liu, Guosheng
supporting information; experimental part, p. 2751 - 2754 (2009/12/04)
The palladium-catalyzed intramolecular hydroamination of allenes was investigated under a dioxygen atmosphere where bathocuproine was used as the ligand. The study tested the reaction of N-(y-allenyl)tosylamide with the proposed Pd-hydride species formed
