115199-84-3

Basic information

• Product Name: 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE
• Synonyms: ICI 199,441 HYDROCHLORIDE;2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE;ICI199441HCl;ICI 199441
• CAS NO: 115199-84-3
• Molecular Formula: C₂₁H₂₄Cl₂N₂O*ClH
• Molecular Weight: 427.8
• Mol File: 115199-84-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 532.8°Cat760mmHg
• Flash Point: 276°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.97E-11mmHg at 25°C
• Storage Temp.: Store at RT
• CAS DataBase Reference: 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE(115199-84-3)
• EPA Substance Registry System: 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE(115199-84-3)

Safety Data

• Hazardous Substances Data: 115199-84-3(Hazardous Substances Data)

Usage

Uses

Opioid agonists exert a broad range of effects on the immune system ranging from inflammatory response modulation to opioid and chemokine receptor expression. ICI 199441 is a selective κ-opioid agonist with analgesic properties.

Biological Activity

Highly potent κ agonist, 146-fold more active than U-50488 (trans-(?-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride ) in vitro .

InChI:InChI=1/C21H24Cl2N2O.ClH/c1-24(21(26)14-16-9-10-18(22)19(23)13-16)20(15-25-11-5-6-12-25)17-7-3-2-4-8-17;/h2-4,7-10,13,20H,5-6,11-12,14-15H2,1H3;1H/t20-;/m1./s1

Upstream product

• 115199-69-4 (-)-2-(3,4-Dichlorophenyl)-N-methyl-N-[2-methyl-1(S)-(pyrrolidin-1-ylmethyl)propyl]acetamide hydrochloride 
• 1151995-69-5 Tubulin Polymerization Inhibitor II 
• 115199-55-8 ETHYL 4-(4-N-BUTYLPHENYL)-4-OXOBUTYRATE 
• 115199-26-3 (E)-Methyl-2-(2-broMoMethylphenyl)-2-MethoxyiMinoacetate 
• 115199-21-8 Benzeneacetic acid, a-(MethoxyiMino)-2-Methyl-, Methyl ester 
• 115198-80-6 TERT-BUTYL N-(2-OXIRANYLMETHYL)CARBAMATE 
• 1151-98-0 APIGENINIDIN CHLORIDE 
• 1151-97-9 2-(2,4-DINITROBENZYL)PYRIDINE 
• 115195-51-2 3-[3-(2,6-dimethylmorpholin-4-yl)-2-methylpropyl]phenol 
• 115-19-5 3-Methyl butynol 
• 1151-94-6 4-METHOXY-4'-NITROBENZOPHENONE 
• 115193-61-8 6-PhenylpicoliniMidaMide hydrochloride 
• 1151-93-5 METHANONE, [4-(DIMETHYLAMINO)PHENYL](4-METHOXYPHENYL)- 
• 115193-13-0 (8alpha,10xi)-6-methyl-8-[(2-propyl-1H-imidazol-1-yl)methyl]ergoline 

Downstream Products

• 115200-30-1 2-(3,4-dichlorophenyl)-N-[1-(3,4-dimethoxyphenyl)-2-pyrrolidin-1-ylethyl]-N-methylacetamide hydrochloride 
• 115200-98-1 3-Pyridineaceticacid,alpha-(methylamino)-(9CI) 
• 115201-07-5 Pyrrolidine, 1-[(3-methyl-2-aziridinyl)carbonyl]-, (2S-cis)- (9CI) 
• 115201-19-9 1H-Benzimidazole-2-aceticacid,5-fluoro-(9CI) 
• 115201-20-2 1H-Benzimidazole-2-acetonitrile,5-fluoro-(9CI) 
• 115201-28-0 HCl-Val-Pyrrolidide 
• 115201-42-8 1-(4-METHOXYBENZYL)-1,2,4-TRIAZOLE 
• 115204-07-4 onnamide 
• 115204-49-4 N-(3-{[6-(dimethylamino)-9H-purin-9-yl]methyl}phenyl)phenylalaninamide 
• 115204-50-7 9-(3-aminobenzyl)-N,N-dimethyl-9H-purin-6-amine 
• 115204-51-8 N-(4-{[6-(dimethylamino)-9H-purin-9-yl]methyl}phenyl)acetamide 
• 115204-52-9 3-{[6-(dimethylamino)-9H-purin-9-yl]methyl}phenol 
• 115204-53-0 9-benzyl-2-chloro-N,N-dimethyl-9H-purin-6-amine 
• 115204-54-1 2-chloro-9-(4-chlorobenzyl)-N,N-dimethyl-9H-purin-6-amine 

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