115199-84-3 Usage
Uses
Opioid agonists exert a broad range of effects on the immune system ranging from inflammatory response modulation to opioid and chemokine receptor expression. ICI 199441 is a selective κ-opioid agonist with analgesic properties.
Biological Activity
Highly potent κ agonist, 146-fold more active than U-50488 (trans-(?-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride ) in vitro .
Check Digit Verification of cas no
The CAS Registry Mumber 115199-84-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,1,9 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 115199-84:
(8*1)+(7*1)+(6*5)+(5*1)+(4*9)+(3*9)+(2*8)+(1*4)=133
133 % 10 = 3
So 115199-84-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H24Cl2N2O.ClH/c1-24(21(26)14-16-9-10-18(22)19(23)13-16)20(15-25-11-5-6-12-25)17-7-3-2-4-8-17;/h2-4,7-10,13,20H,5-6,11-12,14-15H2,1H3;1H/t20-;/m1./s1
115199-84-3Relevant articles and documents
KAPPA AGONIST ANTI-PRURITIC PHARMACEUTICAL FORMULATIONS AND METHOD OF TREATING PRURITUS THEREWITH
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, (2008/06/13)
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2-aminoethylamine derivatives, compositions of the same and use of said compounds in medicine
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, (2008/06/13)
A compound of formula (I): STR1 or a salt and/or solvate thereof, wherein R represents an acyl group containing a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic group; R1 and R2 each independently represents an alkyl, alkenyl or alkynyl group or R1 together with R2 represents a C3-6 polymethylene or alkenylene group; R3 represents hydrogen or alkyl; R4 represents hydrogen, halogen, alkyl, hydroxy, alkoxy, nitrile, nitro, amino or mono or disubstituted amino; and n represents O or an integer 1, is useful in the treatment of pain.