1151990-01-0Relevant academic research and scientific papers
Synthesis and Evaluation of Paclitaxel-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery
Paciotti, Giulio F.,Zhao, Jielu,Cao, Shugeng,Brodie, Peggy J.,Tamarkin, Lawrence,Huhta, Marja,Myer, Lonnie D.,Friedman, Jay,Kingston, David G. I.
, p. 2646 - 2657 (2016/11/28)
The synthesis of a series of thiolated paclitaxel analogs is described as part of a novel nanomedicine program aimed at developing formulations of paclitaxel that will bind to gold nanoparticles for tumor targeted drug delivery. Preliminary evaluation of the new nanomedicine composed of 27 nm gold nanoparticles, tumor necrosis factor alpha (TNFα), thiolated polyethylene glycol (PEG-thiol), and one of several thiolated paclitaxel analogs is presented.
THIOLATED PACLITAXELS FOR REACTION WITH GOLD NANOPARTICLES AS DRUG DELIVERY AGENTS
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Page/Page column 76-77, (2009/06/27)
Thioloated taxane derivatives are linked to colloidal metal particles such as gold nanoparticles for use as antitumor agents. The antitumor agents may be targeted to tumors.
